Literature DB >> 25903205

Protocols cure diseases, not patients: flaccid paresis in post-NSTEMI statin treatment.

Javier Rosada1, Eleni Rebelos1, Stefania Petruccelli1, Marco Taddei1.   

Abstract

An 82-year-old white woman presented at our Internal Medicine ward with flaccid tetraparesis. Two months earlier, she had suffered a non-ST elevation myocardial infarction treated with percutaneous coronary intervention (PCI) and stenting, and she had been prescribed the classical post-PCI therapy (β-blockers, statins and antiplatelet agents). At admission, she was haemodynamically stable and the physical examination revealed reduced reflexes in the four limbs. Urgent laboratory findings revealed mild hypokalaemia. Considering the high statin doses she was taking, we also performed an urgent creatine phosphokinase test, which indicated rhabdomyolysis. Statin therapy was immediately stopped and aggressive fluid treatment begun, supplemented with potassium for increased urinary potassium losses. The patient progressively regained muscle strength. 2015 BMJ Publishing Group Ltd.

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Year:  2015        PMID: 25903205      PMCID: PMC4420829          DOI: 10.1136/bcr-2014-208878

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  8 in total

Review 1.  Statin induced myopathy.

Authors:  Sivakumar Sathasivam; Bryan Lecky
Journal:  BMJ       Date:  2008-11-06

2.  ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation.

Authors:  Ph Gabriel Steg; Stefan K James; Dan Atar; Luigi P Badano; Carina Blömstrom-Lundqvist; Michael A Borger; Carlo Di Mario; Kenneth Dickstein; Gregory Ducrocq; Francisco Fernandez-Aviles; Anthony H Gershlick; Pantaleo Giannuzzi; Sigrun Halvorsen; Kurt Huber; Peter Juni; Adnan Kastrati; Juhani Knuuti; Mattie J Lenzen; Kenneth W Mahaffey; Marco Valgimigli; Arnoud van 't Hof; Petr Widimsky; Doron Zahger
Journal:  Eur Heart J       Date:  2012-08-24       Impact factor: 29.983

3.  Studies of mechanisms and protective maneuvers in myoglobinuric acute renal injury.

Authors:  R A Zager
Journal:  Lab Invest       Date:  1989-05       Impact factor: 5.662

4.  Adverse drug reactions (ADRs) associated with hospital admissions - elderly female patients are at highest risk.

Authors:  C Hofer-Dueckelmann; E Prinz; W Beindl; J Szymanski; G Fellhofer; M Pichler; J Schuler
Journal:  Int J Clin Pharmacol Ther       Date:  2011-10       Impact factor: 1.366

Review 5.  Rhabdomyolysis and HMG-CoA reductase inhibitors.

Authors:  M A Omar; J P Wilson; T S Cox
Journal:  Ann Pharmacother       Date:  2001-09       Impact factor: 3.154

6.  Gender differences in adverse drug reactions.

Authors:  C Tran; S R Knowles; B A Liu; N H Shear
Journal:  J Clin Pharmacol       Date:  1998-11       Impact factor: 3.126

Review 7.  Safety of aggressive lipid management.

Authors:  Michael H Davidson; Jennifer G Robinson
Journal:  J Am Coll Cardiol       Date:  2007-04-16       Impact factor: 24.094

Review 8.  Muscular effects of statins in the elderly female: a review.

Authors:  Shilpa Bhardwaj; Shalini Selvarajah; Eric B Schneider
Journal:  Clin Interv Aging       Date:  2013-01-18       Impact factor: 4.458

  8 in total

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