Nicola M McKeown1, Adela Hruby2, Rikard Landberg3, David M Herrington4, Alice H Lichtenstein5. 1. 1Nutritional Epidemiology Program,Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University,711 Washington Street,9th Floor,Boston,MA 02111,USA. 2. 2Department of Nutrition,Harvard School of Public Health,Boston,MA,USA. 3. 3Department of Food Science,BioCentre,Swedish University of Agricultural Sciences,Uppsala,Sweden. 4. 5Wake Forest Baptist Medical Center,Winston-Salem,NC,USA. 5. 6Cardiovascular Nutrition Laboratory,Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University,Boston,MA,USA.
Abstract
OBJECTIVE: The objective of the present study was to examine the relationship between plasma alkyresorcinol (AR) concentrations, which are biomarkers of whole-grain intake, and atherosclerotic progression over 3 years in postmenopausal women with coronary artery disease. DESIGN:Plasma AR concentrations were measured by a validated GC-MS method in fasting plasma samples. Atherosclerosis progression was assessed using change in mean minimal coronary artery diameter (MCAD) and percentage diameter stenosis (%ST), based on mean proximal vessel diameter across up to ten coronary segments. Dietary intake was estimated using a 126-item interviewer-administered FFQ. SETTING: A prospective study of postmenopausal women participating in the Estrogen Replacement and Atherosclerosis trial. SUBJECTS: For the analysis of plasma AR concentrations and atherosclerotic progression, plasma samples and follow-up data on angiography were available for 182 women. RESULTS:Mean whole-grain intake was 9·6 (se 0·6) servings per week. After multivariate adjustment, no significant associations were observed between plasma AR concentrations and change in mean MCAD or progression of %ST. Plasma AR concentrations were significantly correlated with dietary whole grains (r=0·35, P<0·001), cereal fibre (r=0·33, P<0·001), bran (r=0·15, P=0·05), total fibre (r=0·22, P=0·003) and legume fibre (r=0·15, P=0·04), but not refined grains, fruit fibre or vegetable fibre. CONCLUSIONS:Plasma AR concentrations were not significantly associated with coronary artery progression over a 3-year period in postmenopausal women with coronary artery disease. A moderate association was observed between plasma AR concentrations and dietary whole grains and cereal fibre, suggesting it may be a useful biomarker in observational studies.
RCT Entities:
OBJECTIVE: The objective of the present study was to examine the relationship between plasma alkyresorcinol (AR) concentrations, which are biomarkers of whole-grain intake, and atherosclerotic progression over 3 years in postmenopausal women with coronary artery disease. DESIGN: Plasma AR concentrations were measured by a validated GC-MS method in fasting plasma samples. Atherosclerosis progression was assessed using change in mean minimal coronary artery diameter (MCAD) and percentage diameter stenosis (%ST), based on mean proximal vessel diameter across up to ten coronary segments. Dietary intake was estimated using a 126-item interviewer-administered FFQ. SETTING: A prospective study of postmenopausal women participating in the Estrogen Replacement and Atherosclerosis trial. SUBJECTS: For the analysis of plasma AR concentrations and atherosclerotic progression, plasma samples and follow-up data on angiography were available for 182 women. RESULTS: Mean whole-grain intake was 9·6 (se 0·6) servings per week. After multivariate adjustment, no significant associations were observed between plasma AR concentrations and change in mean MCAD or progression of %ST. Plasma AR concentrations were significantly correlated with dietary whole grains (r=0·35, P<0·001), cereal fibre (r=0·33, P<0·001), bran (r=0·15, P=0·05), total fibre (r=0·22, P=0·003) and legume fibre (r=0·15, P=0·04), but not refined grains, fruit fibre or vegetable fibre. CONCLUSIONS: Plasma AR concentrations were not significantly associated with coronary artery progression over a 3-year period in postmenopausal women with coronary artery disease. A moderate association was observed between plasma AR concentrations and dietary whole grains and cereal fibre, suggesting it may be a useful biomarker in observational studies.