Literature DB >> 2590277

Synthesis, DNA-binding properties, and antitumor activity of novel distamycin derivatives.

F M Arcamone1, F Animati, B Barbieri, E Configliacchi, R D'Alessio, C Geroni, F C Giuliani, E Lazzari, M Menozzi, N Mongelli.   

Abstract

A group of potential alkylating agents have been synthesized that are structurally related to the oligopeptide antiviral antibiotic distamycin. All derivatives form complexes with native calf-thymus DNA but compounds 2, 3, and 6 give rise to covalent adducts. Cytostatic activity against both human and murine tumor cell lines in vitro is displayed by the new compounds. Compounds 3 and 4 are active on melphalan-resistant L1210 leukemia in mice.

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Year:  1989        PMID： 2590277     DOI： 10.1021/jm00124a008

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  18 in total

Review 1.  Anticancer drug discovery and pharmaceutical chemistry: a history.

Authors:  Miguel F Braña; Ana Sánchez-Migallón
Journal:  Clin Transl Oncol       Date:  2006-10       Impact factor: 3.405

2.  Characterization of a protein recognizing minor groove binders-damaged DNA.

Authors:  G Colella; M Bonfanti; M D'Incalci; M Broggini
Journal:  Nucleic Acids Res       Date:  1996-11-01       Impact factor: 16.971

3.  Responsiveness to hormone, growth factor and drug treatment of a human breast cancer cell line: comparison between early and late cultures.

Authors:  A de Cupis; P Pirani; L Fazzuoli; R E Favoni
Journal:  In Vitro Cell Dev Biol Anim       Date:  1998 Nov-Dec       Impact factor: 2.416

4.  The development of new anticancer drugs.

Authors:  F M Arcamone
Journal:  World J Microbiol Biotechnol       Date:  1992-12       Impact factor: 3.312

5.  The sequence specificity of alkylation for a series of benzoic acid mustard and imidazole-containing distamycin analogues: the importance of local sequence conformation.

Authors:  M D Wyatt; M Lee; J A Hartley
Journal:  Nucleic Acids Res       Date:  1997-06-15       Impact factor: 16.971

6.  Backbone and benzoyl mustard carrying moiety modifies DNA interactions of distamycin analogues.

Authors:  A Ciucci; S Manzini; P Lombardi; F Arcamone
Journal:  Nucleic Acids Res       Date:  1996-01-15       Impact factor: 16.971

7.  DNA sequence-specific adenine alkylation by the novel antitumor drug tallimustine (FCE 24517), a benzoyl nitrogen mustard derivative of distamycin.

Authors:  M Broggini; H M Coley; N Mongelli; E Pesenti; M D Wyatt; J A Hartley; M D'Incalci
Journal:  Nucleic Acids Res       Date:  1995-01-11       Impact factor: 16.971

8.  Specific inhibition of human DNA ligase adenylation by a distamycin derivative possessing antitumor activity.

Authors:  A Montecucco; M Fontana; F Focher; M Lestingi; S Spadari; G Ciarrocchi
Journal:  Nucleic Acids Res       Date:  1991-03-11       Impact factor: 16.971

9.  Comparative in vitro myelotoxicity of FCE 24517, a distamycin derivative, to human, canine and murine hematopoietic progenitor cells.

Authors:  D A Volpe; D L Du; M G Zurlo; N Mongelli; M J Murphy
Journal:  Invest New Drugs       Date:  1992-11       Impact factor: 3.850

10.  Differential effects of distamycin analogues on amplification of human gene sequences by polymerase-chain reaction.

Authors:  M Passadore; N Bianchi; G Feriotto; C Mischiati; P Giacomini; R Piva; R Gambari
Journal:  Biochem J       Date:  1995-06-01       Impact factor: 3.857
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