Literature DB >> 2590163

An analysis of myo-[3H]inositol trisphosphates found in myo-[3H]inositol prelabelled avian erythrocytes.

L R Stephens1, P T Hawkins, C P Downes.   

Abstract

Evidence is presented to show that acid extracts of avian erythrocytes prelabelled for 24-48 h with myo-[3H]inositol contain the following myo-[3H]inositol trisphosphates (expressed as a percentage of total myo-[3H]inositol trisphosphates extracted): 36% myo-[3H]inositol 1,4,5-trisphosphate; 33.7% myo-[3H]inositol 1,3,4-trisphosphate; 13% myo-[3H]inositol 3,4,5-trisphosphate; 9.7% myo-[3H]inositol 3,4,6-trisphosphate; 4.4% myo-[3H]inositol 1,4,6-trisphosphate and 3.3% myo-[3H]inositol 1,3,6-trisphosphate. The only phosphatidyl-myo-[3H]inositol bisphosphate that could be detected in [3H]Ins-prelabelled avian erythrocytes was phosphatidyl-myo-[3H]inositol 4,5-bisphosphate. Cellular myo-[3H]inositol 3,4,5-trisphosphate may be synthesized by dephosphorylation of myo-[3H]inositol 3,4,5,6-tetrakisphosphate. D- and L-myo-[3H]inositol 1,4,6-trisphosphate and D- and L-myo-[3H]inositol 1,3,6-trisphosphate may be dephosphorylation products of myo-[3H]inositol 1,3,4,6-tetrakisphosphate.

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Year:  1989        PMID： 2590163      PMCID： PMC1133335          DOI： 10.1042/bj2620727

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  19 in total

1.  The structure of triphosphoinositide from beef brain.

Authors:  D M Brown; J C Stewart
Journal:  Biochim Biophys Acta       Date:  1966-12-07

2.  The hydrolysis of triphosphoinositide by extracts of ox brain.

Authors:  W Thompson; R M Dawson
Journal:  Biochem J       Date:  1964-05       Impact factor: 3.857

3.  The triphosphoinositide phosphomonoesterase of brain tissue.

Authors:  R M Dawson; W Thompson
Journal:  Biochem J       Date:  1964-05       Impact factor: 3.857

4.  A simple assay method for determination of the specific radioactivity of the gamma-phosphate group of 32P-labelled ATP.

Authors:  P T Hawkins; R H Michell; C J Kirk
Journal:  Biochem J       Date:  1983-03-15       Impact factor: 3.857

5.  A high-performance liquid chromatographic method to measure 32P incorporation into phosphorylated metabolites in cultured cells.

Authors:  E S Sharps; R L McCarl
Journal:  Anal Biochem       Date:  1982-08       Impact factor: 3.365

6.  The inositol tris/tetrakisphosphate pathway--demonstration of Ins(1,4,5)P3 3-kinase activity in animal tissues.

Authors:  R F Irvine; A J Letcher; J P Heslop; M J Berridge
Journal:  Nature       Date:  1986 Apr 17-23       Impact factor: 49.962

7.  Metabolic and structural evidence for the existence of a third species of polyphosphoinositide in cells: D-phosphatidyl-myo-inositol 3-phosphate.

Authors:  L Stephens; P T Hawkins; C P Downes
Journal:  Biochem J       Date:  1989-04-01       Impact factor: 3.857

8.  Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices.

Authors:  I R Batty; S R Nahorski; R F Irvine
Journal:  Biochem J       Date:  1985-11-15       Impact factor: 3.857

9.  Inositol trisphosphates in carbachol-stimulated rat parotid glands.

Authors:  R F Irvine; A J Letcher; D J Lander; C P Downes
Journal:  Biochem J       Date:  1984-10-01       Impact factor: 3.857

10.  Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland.

Authors:  C P Downes; P T Hawkins; R F Irvine
Journal:  Biochem J       Date:  1986-09-01       Impact factor: 3.857
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  16 in total

1.  Relationships between the degree of cross-linking of surface immunoglobulin and the associated inositol 1,4,5-trisphosphate and Ca2+ signals in human B cells.

Authors:  F M McConnell; S B Shears; P J Lane; M S Scheibel; E A Clark
Journal:  Biochem J       Date:  1992-06-01       Impact factor: 3.857

2.  Metabolic evidence for PtdIns(4,5)P2-directed phospholipase C in permeabilized plant protoplasts.

Authors:  C A Brearley; P N Parmar; D E Hanke
Journal:  Biochem J       Date:  1997-05-15       Impact factor: 3.857

3.  Measurement of picomole amounts of any inositol phosphate isomer separable by h.p.l.c. by means of a bioluminescence assay.

Authors:  S A Prestwich; T B Bolton
Journal:  Biochem J       Date:  1991-03-15       Impact factor: 3.857

4.  3- and 4-phosphorylated phosphatidylinositols in the aquatic plant Spirodela polyrhiza L.

Authors:  C A Brearley; D E Hanke
Journal:  Biochem J       Date:  1992-04-01       Impact factor: 3.857

5.  Metabolism and possible compartmentalization of inositol lipids in isolated rat-liver nuclei.

Authors:  L R Vann; F B Wooding; R F Irvine; N Divecha
Journal:  Biochem J       Date:  1997-10-15       Impact factor: 3.857

6.  The interrelationships of the inositol phosphates formed in vasopressin-stimulated WRK-1 rat mammary tumour cells.

Authors:  C J Barker; N S Wong; S M Maccallum; P A Hunt; R H Michell; C J Kirk
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857

7.  The inositol phosphates in WRK1 rat mammary tumour cells.

Authors:  N S Wong; C J Barker; A J Morris; A Craxton; C J Kirk; R H Michell
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857

8.  myo-inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo-inositol hexakisphosphate.

Authors:  L R Stephens; P T Hawkins; A F Stanley; T Moore; D R Poyner; P J Morris; M R Hanley; R R Kay; R F Irvine
Journal:  Biochem J       Date:  1991-04-15       Impact factor: 3.857

9.  Activation of PLC by an endogenous cytokine (GBP) in Drosophila S3 cells and its application as a model for studying inositol phosphate signalling through ITPK1.

Authors:  Yixing Zhou; Shilan Wu; Huanchen Wang; Yoichi Hayakawa; Gary S Bird; Stephen B Shears
Journal:  Biochem J       Date:  2012-12-01       Impact factor: 3.857

10.  Molecular characterization of an Arabidopsis gene encoding a phospholipid-specific inositol polyphosphate 5-phosphatase.

Authors:  Mustafa E Ercetin; Glenda E Gillaspy
Journal:  Plant Physiol       Date:  2004-06-04       Impact factor: 8.340
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