Literature DB >> 25901206

Influence of microRNA-related polymorphisms on clinical outcomes in coronary artery disease.

Qianzhen Li1, Liangwan Chen1, Daozhong Chen1, Xijie Wu1, Meifang Chen1.   

Abstract

Genetic variants in pre-microRNA (miRNA) genes or the 3'UTR of miRNA target genes could influence miRNA-mediated regulation of gene expression and thus contribute to the susceptibility and prognosis of human diseases. This study aimed to investigate the effect of 6 miRNA-related polymorphisms (miR-149 rs71428439, miR-146a rs2910164, miR-499 rs3746444, miR-423 rs6505162, miR-4513 rs2168518, and FABP2 rs11724758) on prognosis in 1004 patients with angiographic coronary artery disease (CAD). We found that miR-4513 rs2168518 was associated with blood pressure, triglycerides, total cholesterol, and fasting glucose levels, and risk of diabetes mellitus. miR-499 rs3746444 and miR-423 rs6505162 were associated with blood pressure and HDL levels, respectively. Both miR-4513 rs2168518 and miR-499 rs3746444 had significant impact on even-free survival. Furthermore, miR-4513 rs2168518 was associated with higher morality in CAD patients. In conclusion, miR-4513 rs2168518 and miR-499 rs3746444 might be potential biomarkers for the clinical prognosis of CAD.

Entities:  

Keywords:  Coronary artery disease; cardiovascular event; lipid; microRNA; mortality; polymorphism

Year:  2015        PMID： 25901206      PMCID： PMC4399102     

Source DB:  PubMed          Journal:  Am J Transl Res            Impact factor:   4.060


  29 in total

1.  Polymorphisms of miRNAs genes are associated with the risk and prognosis of coronary artery disease.

Authors:  Hong Zhi; Lina Wang; Genshan Ma; Xingzhou Ye; Xiaojin Yu; Yi Zhu; Yu Zhang; Jiaju Zhang; Bei Wang
Journal:  Clin Res Cardiol       Date:  2011-12-11       Impact factor: 5.460

2.  miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1.

Authors:  Jian-Xun Wang; Jian-Qin Jiao; Qian Li; Bo Long; Kun Wang; Jin-Ping Liu; Yan-Rui Li; Pei-Feng Li
Journal:  Nat Med       Date:  2010-12-26       Impact factor: 53.440

3.  A SNARE involved in protein transport through the Golgi apparatus.

Authors:  S L Lowe; F Peter; V N Subramaniam; S H Wong; W Hong
Journal:  Nature       Date:  1997-10-23       Impact factor: 49.962

4.  Association of microRNA polymorphisms with the risk of myocardial infarction in a Chinese population.

Authors:  Cunrong Chen; Huashan Hong; Lianglong Chen; Xiaoyun Shi; Ying Chen; Qinyong Weng
Journal:  Tohoku J Exp Med       Date:  2014-06       Impact factor: 1.848

5.  Genomic dissection of population substructure of Han Chinese and its implication in association studies.

Authors:  Shuhua Xu; Xianyong Yin; Shilin Li; Wenfei Jin; Haiyi Lou; Ling Yang; Xiaohong Gong; Hongyan Wang; Yiping Shen; Xuedong Pan; Yungang He; Yajun Yang; Yi Wang; Wenqing Fu; Yu An; Jiucun Wang; Jingze Tan; Ji Qian; Xiaoli Chen; Xin Zhang; Yangfei Sun; Xuejun Zhang; Bailin Wu; Li Jin
Journal:  Am J Hum Genet       Date:  2009-12       Impact factor: 11.025

6.  Genetic polymorphisms in pre-microRNAs and risk of ischemic stroke in a Chinese population.

Authors:  Yun Liu; Ying Ma; Bo Zhang; Shun-Xian Wang; Xiao-Ming Wang; Ju-Ming Yu
Journal:  J Mol Neurosci       Date:  2013-11-01       Impact factor: 3.444

7.  Upregulation of miR-301a correlates with poor prognosis in triple-negative breast cancer.

Authors:  Hong Yu; Hui Li; Hua Qian; Xia Jiao; Xiaowei Zhu; Xiaoqin Jiang; Guihong Dai; Junxing Huang
Journal:  Med Oncol       Date:  2014-10-14       Impact factor: 3.064

8.  Prognostic value of miR-221-3p, miR-342-3p and miR-491-5p expression in colon cancer.

Authors:  Kun Tao; Jing Yang; Zhenhua Guo; Yuemei Hu; Haihui Sheng; Hengjun Gao; Hongyu Yu
Journal:  Am J Transl Res       Date:  2014-07-18       Impact factor: 4.060

9.  miRBase: annotating high confidence microRNAs using deep sequencing data.

Authors:  Ana Kozomara; Sam Griffiths-Jones
Journal:  Nucleic Acids Res       Date:  2013-11-25       Impact factor: 16.971

10.  Age-related changes in microRNA levels in serum.

Authors:  Nicole Noren Hooten; Megan Fitzpatrick; William H Wood; Supriyo De; Ngozi Ejiogu; Yongqing Zhang; Julie A Mattison; Kevin G Becker; Alan B Zonderman; Michele K Evans
Journal:  Aging (Albany NY)       Date:  2013-10       Impact factor: 5.682
View more
  20 in total

1.  Molecular Determination of Vascular Endothelial Growth Factor, miRNA-423 Gene Abnormalities by Utilizing ARMS-PCR and Their Association with Fetal Hemoglobin Expression in the Patients with Sickle Cell Disease.

Authors:  Abdullah Hamadi; Rashid Mir; Ali Mahzari; Abdulrahim Hakami; Reema Almotairi; Gasim Dobie; Fawaz Hamdi; Mohammed Hassan Nahari; Razan Alhefzi; Mohammed Alasseiri; Nora Y Hakami; Hadeel Al Sadoun; Osama M Al-Amer; Jameel Barnawi; Hassan A Madkhali
Journal:  Curr Issues Mol Biol       Date:  2022-06-01       Impact factor: 2.976

2.  Improvement of Myocardial Cell Injury by miR-199a-3p/mTOR Axis through Regulating Cell Apoptosis and Autophagy.

Authors:  Weixiong Wu; Xingfeng Chen; Qingyang Hu; Xuefei Wang; Jingyu Zhu; Qianzhen Li
Journal:  J Immunol Res       Date:  2022-06-22       Impact factor: 4.493

3.  Pleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD).

Authors:  Christina Kiel; Tobias Strunz; Felix Grassmann; Bernhard H F Weber
Journal:  Cells       Date:  2020-10-08       Impact factor: 6.600

Review 4.  Epigenetics and Cardiovascular Disease in Diabetes.

Authors:  Jennifer Pasquier; Jessica Hoarau-Véchot; Khalid Fakhro; Arash Rafii; Charbel Abi Khalil
Journal:  Curr Diab Rep       Date:  2015-12       Impact factor: 4.810

5.  Precursor miR-499a Variant but not miR-196a2 is Associated with Rheumatoid Arthritis Susceptibility in an Egyptian Population.

Authors:  Eman A Toraih; Nesreen M Ismail; Ahmed A Toraih; Mohammad H Hussein; Manal S Fawzy
Journal:  Mol Diagn Ther       Date:  2016-06       Impact factor: 4.074

6.  Association study of miR-149, miR-196a2, and miR-499a polymorphisms with coronary artery aneurysm of Kawasaki disease in southern Chinese population.

Authors:  Lanyan Fu; Yufen Xu; Hongyan Yu; Lei Pi; Jinqing Li; Huazhong Zhou; Li Zhang; Tingfang Zhang; Di Che; Xiaoqiong Gu
Journal:  J Gene Med       Date:  2022-01-30       Impact factor: 4.152

7.  Two Single Nucleotide Polymorphisms (rs2431697 and rs2910164) of miR-146a Are Associated with Risk of Coronary Artery Disease.

Authors:  Yaqin Wang; Xintong Wang; Zhenyu Li; Lulu Chen; Luping Zhou; Chaopeng Li; Dong-Sheng Ouyang
Journal:  Int J Environ Res Public Health       Date:  2017-05-10       Impact factor: 3.390

Review 8.  MicroRNAs and Cardiovascular Disease in Diabetes Mellitus.

Authors:  Yue Ding; Xue Sun; Peng-Fei Shan
Journal:  Biomed Res Int       Date:  2017-02-12       Impact factor: 3.411

9.  A systematic analysis highlights multiple long non-coding RNAs associated with cardiometabolic disorders.

Authors:  Marjolein J Peters; Paul S de Vries; Mohsen Ghanbari; Cindy G Boer; Jeroen G J van Rooij; Yu-Chi Lee; Vinod Kumar; André G Uitterlinden; M Arfan Ikram; Cisca Wijmenga; Jose M Ordovas; Caren E Smith; Joyce B J van Meurs; Stefan J Erkeland; Oscar H Franco; Abbas Dehghan
Journal:  J Hum Genet       Date:  2018-01-30       Impact factor: 3.172

10.  Serum VEGF Predicts Worse Clinical Outcome of Patients with Coronary Heart Disease After Percutaneous Coronary Intervention Therapy.

Authors:  Xia Han; Lili Liu; Jiamin Niu; Jun Yang; Zengtang Zhang; Zhiqiang Zhang
Journal:  Med Sci Monit       Date:  2015-10-26
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.