Thomas Yates1, Joseph Henson1, Charlotte Edwardson2, David Dunstan3, Danielle H Bodicoat1, Kamlesh Khunti4, Melanie J Davies1. 1. Diabetes Research Centre, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK; NIHR Leicester-Loughborough Diet, Lifestyle, and Physical Activity Biomedical Research Unit, UK. 2. Diabetes Research Centre, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK; NIHR Leicester-Loughborough Diet, Lifestyle, and Physical Activity Biomedical Research Unit, UK. Electronic address: ce95@le.ac.uk. 3. Physical Activity Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia. 4. Diabetes Research Centre, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK; NIHR Collaboration for Leadership in Applied Health Research and Care-East Midlands (NIHR CLAHRC-EM), UK.
Abstract
OBJECTIVE: The aim of this study is to quantify associations between objectively measured sedentary time and markers of insulin sensitivity by considering allocation into light-intensity physical activity or moderate- to vigorous-intensity physical activity (MVPA). METHODS: Participants with an increased risk of impaired glucose regulation (IGR) were recruited (Leicestershire, United Kingdom, 2010-2011). Sedentary, light-intensity physical activity and MVPA time were measured using accelerometers. Fasting and 2-hour post-challenge insulin and glucose were assessed; insulin sensitivity was calculated by HOMA-IS and Matsuda-ISI. Isotemporal substitution regression models were used. Data were analysed in 2014. RESULTS: 508 participants were included (average age=65years, female=34%). Reallocating 30min of sedentary time into light-intensity physical activity was associated a 5% (95% CI 1, 9%; p=0.024) difference in Matsuda-ISI after adjustment for measured confounding variables. Reallocation into MVPA was associated with a 15% (7, 25%; p<0.001) difference in HOMA-IS and 18% (8, 28%; p<0.001) difference in Matsuda-ISI. Results for light-intensity physical activity were modified by IGR status with stronger associations seen in those with IGR. CONCLUSIONS: Reallocating sedentary time into light-intensity physical activity or MVPA was associated with differences in insulin sensitivity, with stronger and more consistent associations seen for MVPA.
OBJECTIVE: The aim of this study is to quantify associations between objectively measured sedentary time and markers of insulin sensitivity by considering allocation into light-intensity physical activity or moderate- to vigorous-intensity physical activity (MVPA). METHODS:Participants with an increased risk of impaired glucose regulation (IGR) were recruited (Leicestershire, United Kingdom, 2010-2011). Sedentary, light-intensity physical activity and MVPA time were measured using accelerometers. Fasting and 2-hour post-challenge insulin and glucose were assessed; insulin sensitivity was calculated by HOMA-IS and Matsuda-ISI. Isotemporal substitution regression models were used. Data were analysed in 2014. RESULTS: 508 participants were included (average age=65years, female=34%). Reallocating 30min of sedentary time into light-intensity physical activity was associated a 5% (95% CI 1, 9%; p=0.024) difference in Matsuda-ISI after adjustment for measured confounding variables. Reallocation into MVPA was associated with a 15% (7, 25%; p<0.001) difference in HOMA-IS and 18% (8, 28%; p<0.001) difference in Matsuda-ISI. Results for light-intensity physical activity were modified by IGR status with stronger associations seen in those with IGR. CONCLUSIONS: Reallocating sedentary time into light-intensity physical activity or MVPA was associated with differences in insulin sensitivity, with stronger and more consistent associations seen for MVPA.
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