OBJECTIVES: To study the interaction between and timing effects of depression and vascular disorders on dementia risk. DESIGN: Retrospective cohort study. SETTING: Primary care practices in the south of the Netherlands. PARTICIPANTS: Individuals in primary care aged 50 to 100 followed for 13 years (N = 35,791). MEASUREMENTS: Medical diagnoses of incident depression, hypertension, obesity, type 2 diabetes mellitus, stroke, and dementia were extracted from a research database. Cox proportional hazards regression was used to test whether incident depression predicted dementia and its putative interactions with vascular factors. RESULTS: In total, 1,680 participants developed dementia. Individuals with depression (n = 978) had a higher risk of dementia (adjusted hazard ratio (HR) = 2.03, 95% confidence interval (CI) = 1.56-2.64). Depression exerted most effect in participants with incident stroke (HR = 5.29, 95% CI = 2.52-11.14) or newly diagnosed hypertension (HR = 3.09, 95% CI = 1.54-6.20). CONCLUSION: Depression in later life increases the risk of dementia. The effect is particularly high in individuals with depression and vascular disorders. Targeting late-onset depression in individuals with vascular disorders might lower dementia risk by preventing cerebrovascular changes.
OBJECTIVES: To study the interaction between and timing effects of depression and vascular disorders on dementia risk. DESIGN: Retrospective cohort study. SETTING: Primary care practices in the south of the Netherlands. PARTICIPANTS: Individuals in primary care aged 50 to 100 followed for 13 years (N = 35,791). MEASUREMENTS: Medical diagnoses of incident depression, hypertension, obesity, type 2 diabetes mellitus, stroke, and dementia were extracted from a research database. Cox proportional hazards regression was used to test whether incident depression predicted dementia and its putative interactions with vascular factors. RESULTS: In total, 1,680 participants developed dementia. Individuals with depression (n = 978) had a higher risk of dementia (adjusted hazard ratio (HR) = 2.03, 95% confidence interval (CI) = 1.56-2.64). Depression exerted most effect in participants with incident stroke (HR = 5.29, 95% CI = 2.52-11.14) or newly diagnosed hypertension (HR = 3.09, 95% CI = 1.54-6.20). CONCLUSION:Depression in later life increases the risk of dementia. The effect is particularly high in individuals with depression and vascular disorders. Targeting late-onset depression in individuals with vascular disorders might lower dementia risk by preventing cerebrovascular changes.
Authors: Priscila Corraini; Victor W Henderson; Anne G Ording; Lars Pedersen; Erzsébet Horváth-Puhó; Henrik T Sørensen Journal: Stroke Date: 2016-11-29 Impact factor: 7.914
Authors: Howard J Aizenstein; Andrius Baskys; Maura Boldrini; Meryl A Butters; Breno S Diniz; Manoj Kumar Jaiswal; Kurt A Jellinger; Lev S Kruglov; Ivan A Meshandin; Milija D Mijajlovic; Guenter Niklewski; Sarah Pospos; Keerthy Raju; Kneginja Richter; David C Steffens; Warren D Taylor; Oren Tene Journal: BMC Med Date: 2016-11-03 Impact factor: 8.775
Authors: Elizabeth Ford; Nicholas Greenslade; Priya Paudyal; Stephen Bremner; Helen E Smith; Sube Banerjee; Shanu Sadhwani; Philip Rooney; Seb Oliver; Jackie Cassell Journal: PLoS One Date: 2018-03-29 Impact factor: 3.240
Authors: Sara N Rushia; Al Amira Safa Shehab; Jeffrey N Motter; Dakota A Egglefield; Sophie Schiff; Joel R Sneed; Ernst Garcon Journal: World J Radiol Date: 2020-05-28