Yuliya Snyder1, Colleen Donlin-Smith1, Eric Snyder1, Eva Pressman2, Emma Ciafaloni1. 1. Department of Neurology, University of Rochester Medical Center, 607 Elmwood Avenue, Rochester, P.O. Box 673, Rochester, New York, 14642, USA. 2. Department of Obstetrics and Gynecology, University of Rochester Medical Center, 607 Elmwood Avenue, Rochester, P.O. Box 673, Rochester, New York, 14642, USA.
Abstract
INTRODUCTION: Nondystrophic myotonias (NDM) are muscle channelopathies characterized by clinical and electrical myotonia. Little is known about pregnancy in NDM. The aim of this work was to assess pregnancy outcomes in women with NDM. METHODS: In this investigation, we utilized a cross-sectional approach and obtained questionnaire data and medical record review information. Pregnancy outcomes were compared with U.S. national data. RESULTS: Twenty-five women completed the study. There were 63 pregnancies with 53 live births, 8 miscarriages, 4 terminations, and 1 stillbirth. The infertility rate was 28% (above the U.S. average). Fetal distress was reported in 11.7% (U.S. average 3.6%) of the patients. NDM symptoms worsened in 62% of pregnancies. In those who worsened, symptoms usually resolved completely (66%) or partially (32%) after delivery in 2 days to 12 months, the majority (76%) within 3 months. CONCLUSIONS: Most pregnancy outcomes were favorable. NDM worsened in nearly two-thirds of pregnancies, but usually improved shortly after delivery. Incidences of infertility and fetal distress were higher than overall U.S. rates.
INTRODUCTION:Nondystrophic myotonias (NDM) are muscle channelopathies characterized by clinical and electrical myotonia. Little is known about pregnancy in NDM. The aim of this work was to assess pregnancy outcomes in women with NDM. METHODS: In this investigation, we utilized a cross-sectional approach and obtained questionnaire data and medical record review information. Pregnancy outcomes were compared with U.S. national data. RESULTS: Twenty-five women completed the study. There were 63 pregnancies with 53 live births, 8 miscarriages, 4 terminations, and 1 stillbirth. The infertility rate was 28% (above the U.S. average). Fetal distress was reported in 11.7% (U.S. average 3.6%) of the patients. NDM symptoms worsened in 62% of pregnancies. In those who worsened, symptoms usually resolved completely (66%) or partially (32%) after delivery in 2 days to 12 months, the majority (76%) within 3 months. CONCLUSIONS: Most pregnancy outcomes were favorable. NDM worsened in nearly two-thirds of pregnancies, but usually improved shortly after delivery. Incidences of infertility and fetal distress were higher than overall U.S. rates.
Authors: Bas C Stunnenberg; Samantha LoRusso; W David Arnold; Richard J Barohn; Stephen C Cannon; Bertrand Fontaine; Robert C Griggs; Michael G Hanna; Emma Matthews; Giovanni Meola; Valeria A Sansone; Jaya R Trivedi; Baziel G M van Engelen; Savine Vicart; Jeffrey M Statland Journal: Muscle Nerve Date: 2020-05-27 Impact factor: 3.217