Hélio A G Teive1, Walter O Arruda2, Adriana Moro2, Mariana Moscovich2, Renato P Munhoz3. 1. Movement Disorders Unit, Neurology Service, Internal Medicine Department, Hospital de Clínicas, Federal University of Paraná, Curitiba, PR, Brazil. Electronic address: hagteive@mps.com.br. 2. Movement Disorders Unit, Neurology Service, Internal Medicine Department, Hospital de Clínicas, Federal University of Paraná, Curitiba, PR, Brazil. 3. Movement Disorders Centre, Toronto Western Hospital, University of Toronto, Toronto, Canada.
Abstract
BACKGROUND: Sporadic adult-onset ataxia encompasses a group of degenerative, non-hereditary disorders, including idiopathic adult-onset ataxia and the cerebellar form of multiple system atrophy. Our objective was to analyze the diagnosis at follow-up of 50 sporadic adult-onset ataxia patients. METHODS: Clinical and laboratory findings of 50 adult patients with sporadic adult-onset ataxia were analyzed. Diagnosis of probable REM sleep behavior disorder was based predominantly on clinically accepted criteria. RESULTS: Multiple system atrophy was diagnosed in 48% of cases, the remaining 52% received a diagnosis of sporadic adult-onset ataxia. REM sleep behavior disorder was diagnosed in 46% of the patients. However, among patients with probable multiple system atrophy, the corresponding figure was 83.34% versus 11.53% among those with sporadic ataxia (p < 0.001). CONCLUSIONS: REM sleep behavior disorder is an important aid to the differentiation of multiple system atrophy from sporadic adult-onset ataxia and its use for this purpose should be encouraged.
BACKGROUND: Sporadic adult-onset ataxia encompasses a group of degenerative, non-hereditary disorders, including idiopathic adult-onset ataxia and the cerebellar form of multiple system atrophy. Our objective was to analyze the diagnosis at follow-up of 50 sporadic adult-onset ataxiapatients. METHODS: Clinical and laboratory findings of 50 adult patients with sporadic adult-onset ataxia were analyzed. Diagnosis of probable REM sleep behavior disorder was based predominantly on clinically accepted criteria. RESULTS:Multiple system atrophy was diagnosed in 48% of cases, the remaining 52% received a diagnosis of sporadic adult-onset ataxia. REM sleep behavior disorder was diagnosed in 46% of the patients. However, among patients with probable multiple system atrophy, the corresponding figure was 83.34% versus 11.53% among those with sporadic ataxia (p < 0.001). CONCLUSIONS:REM sleep behavior disorder is an important aid to the differentiation of multiple system atrophy from sporadic adult-onset ataxia and its use for this purpose should be encouraged.
Authors: Iva Stankovic; Alessandra Fanciulli; Vladimir S Kostic; Florian Krismer; Wassilios G Meissner; Jose Alberto Palma; Jalesh N Panicker; Klaus Seppi; Gregor K Wenning Journal: Mov Disord Clin Pract Date: 2021-03-10