Literature DB >> 2589893

Prognostic significance of DNA content abnormalities in young patients with colorectal cancer.

T M Heimann1, G Martinelli, A Szporn, R J Kurtz, A Quish, F Miller, S C Oh, T Fasy.   

Abstract

Several studies have shown that the presence of DNA ploidy abnormalities, measured by flow cytometry, may correlate with a poor prognosis in a variety of cancers. The predictive value of these DNA abnormalities in young patients with colorectal cancer has not been well studied. Fifty patients aged 40 years and younger with colorectal adenocarcinoma were studied to determine the correlation of tumor DNA abnormalities with survival. DNA content was determined by flow cytometric analysis and each tumor was categorized as diploid or nondiploid. Of the parameters studied, Dukes' classification and tumor DNA ploidy were found to be significant prognostic indicators. Determination of DNA content seems to provide additional useful prognostic information in young patients with colorectal cancer.

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Year:  1989        PMID： 2589893      PMCID： PMC1357874     

Source DB:  PubMed          Journal:  Ann Surg        ISSN： 0003-4932            Impact factor:   12.969


  22 in total

1.  Prognostic significance of DNA aneuploidy in stage I cutaneous melanoma.

Authors:  S M Kheir; S D Bines; J H Vonroenn; S J Soong; M M Urist; J S Coon
Journal:  Ann Surg       Date:  1988-04       Impact factor: 12.969

2.  Colorectal cancer in patients under 40 years of age.

Authors:  M Adloff; J P Arnaud; M Schloegel; D Thibaud; R Bergamaschi
Journal:  Dis Colon Rectum       Date:  1986-05       Impact factor: 4.585

3.  Prognostic value of DNA content in colorectal carcinoma. A flow cytometric study with some methodologic aspects.

Authors:  S O Emdin; R Stenling; G Roos
Journal:  Cancer       Date:  1987-09-15       Impact factor: 6.860

4.  Association of DNA index and S-phase fraction with prognosis of nodes positive early breast cancer.

Authors:  D W Hedley; C A Rugg; R D Gelber
Journal:  Cancer Res       Date:  1987-09-01       Impact factor: 12.701

5.  Tumor DNA content in primary and metastatic colorectal carcinoma.

Authors:  W A Kokal; R B Duda; N Azumi; K Sheibani; M M Kemeny; J J Terz; J R Harada
Journal:  Arch Surg       Date:  1986-12

6.  Colorectal cancer. Dukes' stage, tumor site, preoperative plasma CEA level, and patient prognosis related to tumor DNA ploidy pattern.

Authors:  N A Scott; H S Wieand; C G Moertel; S S Cha; R W Beart; M M Lieber
Journal:  Arch Surg       Date:  1987-12

7.  The relative prognostic value of flow cytometric DNA analysis and conventional clinicopathologic criteria in patients with operable rectal carcinoma.

Authors:  N A Scott; L M Rainwater; H S Wieand; L H Weiland; J H Pemberton; R W Beart; M M Lieber
Journal:  Dis Colon Rectum       Date:  1987-07       Impact factor: 4.585

8.  Association of antigen expression and DNA ploidy in human colorectal tumors.

Authors:  L G Durrant; R A Robins; N C Armitage; A Brown; R W Baldwin; J D Hardcastle
Journal:  Cancer Res       Date:  1986-07       Impact factor: 12.701

9.  Results of surgical treatment for familial polyposis coli.

Authors:  T M Heimann; K Bolnick; A H Aufses
Journal:  Am J Surg       Date:  1986-09       Impact factor: 2.565

10.  Should flow cytometric DNA analysis precede definitive surgery for colon carcinoma?

Authors:  B F Banner; J E Tomas-De La Vega; D L Roseman; J S Coon
Journal:  Ann Surg       Date:  1985-12       Impact factor: 12.969
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  3 in total

1.  The prognostic value of nucleolar organiser regions in colorectal cancer: a 5-year follow-up study.

Authors:  W P Joyce; M Fynes; K T Moran; D B Gough; P Dervan; T F Gorey; J M Fitzpatrick
Journal:  Ann R Coll Surg Engl       Date:  1992-05       Impact factor: 1.891

2.  Survival with colorectal cancer in ulcerative colitis. A study of 102 cases.

Authors:  A Sugita; A J Greenstein; M B Ribeiro; D B Sachar; C Bodian; A K Panday; A Szporn; J Pozner; T Heimann; M Palmer
Journal:  Ann Surg       Date:  1993-08       Impact factor: 12.969

3.  Relationships among tenascin expression, DNA ploidy patterns, and multidrug resistance gene product (P-glycoprotein) in human colon carcinoma.

Authors:  I Sugawara; J Hirakoshi; M Kusakabe; A Masunaga; S Itoyama; T Sakakura
Journal:  Jpn J Cancer Res       Date:  1993-07
  3 in total

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