| Literature DB >> 25898835 |
Yang Yang1, Weihua Zhang1, Lin Meng1, Haitao Yu1, Na Lu1, Gang Fu1, Yang Zheng2.
Abstract
Inflammation and its subsequent endothelial dysfunction have been reported to play a pivotal role in the initiation and progression of chronic vascular diseases. Inhibiting the attachment of monocytes to endothelium is a potential therapeutic strategy for vascular diseases treatment. α-Melanocyte stimulating hormone is generated from a precursor hormone called proopiomelanocortin by post-translational processing. However, whether α-melanocyte stimulating hormone plays a role in regulating endothelial inflammation is still unknown. In this study, the effects of α-melanocyte stimulating hormone on endothelial inflammation in human umbilical vein endothelial cell lines were investigated. And the result indicated that α-melanocyte stimulating hormone inhibits the expression of endothelial adhesion molecules, including vascular adhesion molecule-1 and E-selectin, thereby attenuating the adhesion of THP-1 cells to the surface of endothelial cells. Mechanistically, α-melanocyte stimulating hormone was found to inhibit NF-κB transcriptional activity. Finally, we found that the effect of α-melanocyte stimulating hormone on endothelial inflammation is dependent on its receptor melanocortin receptor 1.Entities:
Keywords: NF-κB; VCAM-1; endothelial inflammation; α-Melanocyte stimulating hormone
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Year: 2015 PMID： 25898835 PMCID： PMC4935305 DOI： 10.1177/1535370215581307
Source DB: PubMed Journal: Exp Biol Med (Maywood) ISSN： 1535-3699