Literature DB >> 2589847

Combination effect of recombinant human interleukin-1 alpha with antimicrobial agents.

S Nakamura1, A Minami, K Fujimoto, T Kojima.   

Abstract

Combination effects of recombinant human interleukin-1 alpha with ceftazidime, moxalactam, gentamicin, enoxacin, amphotericin B, miconazole, or an immunoglobulin preparation were evaluated in systemic infections with Pseudomonas aeruginosa, Klebsiella pneumoniae, and Candida albicans in normal mice and systemic infection with P. aeruginosa in mice with leukopenia induced by preadministration of cyclophosphamide. Synergistic effects were generally observed at interleukin-1 alpha doses as low as 1 to 30 ng per mouse with most combinations. The results show the possibility that recombinant human interleukin-1 alpha could be of help for treating obstinate infections not successfully treated with antimicrobial agents alone.

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Year:  1989        PMID： 2589847      PMCID： PMC172759          DOI： 10.1128/AAC.33.10.1804

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

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  3 in total

1.  Some pharmacokinetic parameters and dosage regimens for a long-acting formulation of oxytetracycline in 6- to 8-month-old male calves.

Authors:  R Kumar; J K Malik
Journal:  Vet Res Commun       Date:  1998-12       Impact factor: 2.459

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Journal:  Infect Immun       Date:  1992-10       Impact factor: 3.441

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Journal:  Antimicrob Agents Chemother       Date:  1992-06       Impact factor: 5.191
  3 in total

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