Literature DB >> 25896577

Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors.

Mayako Michino1, R Benjamin Free, Trevor B Doyle, David R Sibley, Lei Shi.   

Abstract

To understand the structural basis for the Na(+)-sensitivity of ligand binding to dopamine D2-like receptors, using computational analysis in combination with binding assays, we identified interactions critical in propagating the impact of Na(+) on receptor conformations and on the ligand-binding site. Our findings expand the pharmacologically-relevant conformational spectrum of these receptors.

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Year:  2015        PMID： 25896577      PMCID： PMC5234269          DOI： 10.1039/c5cc02204e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  23 in total

1.  The binding-site crevice of the D4 dopamine receptor is coupled to three distinct sites of allosteric modulation.

Authors:  J A Schetz; D R Sibley
Journal:  J Pharmacol Exp Ther       Date:  2001-02       Impact factor: 4.030

2.  Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist.

Authors:  Ellen Y T Chien; Wei Liu; Qiang Zhao; Vsevolod Katritch; Gye Won Han; Michael A Hanson; Lei Shi; Amy Hauck Newman; Jonathan A Javitch; Vadim Cherezov; Raymond C Stevens
Journal:  Science       Date:  2010-11-19       Impact factor: 47.728

Review 3.  What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?

Authors:  Mayako Michino; Thijs Beuming; Prashant Donthamsetti; Amy Hauck Newman; Jonathan A Javitch; Lei Shi
Journal:  Pharmacol Rev       Date:  2015       Impact factor: 25.468

4.  Opiate agonists and antagonists discriminated by receptor binding in brain.

Authors:  C B Pert; G Pasternak; S H Snyder
Journal:  Science       Date:  1973-12-28       Impact factor: 47.728

5.  Sodium-dependent isomerization of dopamine D-2 receptors characterized using [125I]epidepride, a high-affinity substituted benzamide ligand.

Authors:  K A Neve; R A Henningsen; J M Kinzie; T De Paulis; D E Schmidt; R M Kessler; A Janowsky
Journal:  J Pharmacol Exp Ther       Date:  1990-03       Impact factor: 4.030

6.  Induced effects of sodium ions on dopaminergic G-protein coupled receptors.

Authors:  Jana Selent; Ferran Sanz; Manuel Pastor; Gianni De Fabritiis
Journal:  PLoS Comput Biol       Date:  2010-08-12       Impact factor: 4.475

7.  Identification of essential residues involved in the allosteric modulation of the human A(3) adenosine receptor.

Authors:  Zhan-Guo Gao; Soo-Kyung Kim; Ariel S Gross; Aishe Chen; Joshua B Blaustein; Kenneth A Jacobson
Journal:  Mol Pharmacol       Date:  2003-05       Impact factor: 4.436

8.  The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints.

Authors:  Robert Fredriksson; Malin C Lagerström; Lars-Gustav Lundin; Helgi B Schiöth
Journal:  Mol Pharmacol       Date:  2003-06       Impact factor: 4.436

9.  A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors.

Authors:  Mayako Michino; Prashant Donthamsetti; Thijs Beuming; Ashwini Banala; Lihua Duan; Thomas Roux; Yang Han; Eric Trinquet; Amy Hauck Newman; Jonathan A Javitch; Lei Shi
Journal:  Mol Pharmacol       Date:  2013-09-23       Impact factor: 4.436

10.  Pivotal role of an aspartate residue in sodium sensitivity and coupling to G proteins of neurotensin receptors.

Authors:  S Martin; J M Botto; J P Vincent; J Mazella
Journal:  Mol Pharmacol       Date:  1999-02       Impact factor: 4.436
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  19 in total

1.  Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays.

Authors:  Hideaki Yano; Alessandro Bonifazi; Min Xu; Daryl A Guthrie; Stephanie N Schneck; Ara M Abramyan; Andrew D Fant; W Conrad Hong; Amy H Newman; Lei Shi
Journal:  Neuropharmacology       Date:  2018-01-31       Impact factor: 5.250

2.  Investigating Small-Molecule Ligand Binding to G Protein-Coupled Receptors with Biased or Unbiased Molecular Dynamics Simulations.

Authors:  Kristen A Marino; Marta Filizola
Journal:  Methods Mol Biol       Date:  2018

3.  Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor.

Authors:  Mayako Michino; Comfort A Boateng; Prashant Donthamsetti; Hideaki Yano; Oluyomi M Bakare; Alessandro Bonifazi; Michael P Ellenberger; Thomas M Keck; Vivek Kumar; Clare Zhu; Ravi Verma; Jeffrey R Deschamps; Jonathan A Javitch; Amy Hauck Newman; Lei Shi
Journal:  J Med Chem       Date:  2017-01-05       Impact factor: 7.446

4.  The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor.

Authors:  Christopher J Draper-Joyce; Mayako Michino; Ravi Kumar Verma; Carmen Klein Herenbrink; Jeremy Shonberg; Anitha Kopinathan; Peter J Scammells; Ben Capuano; David M Thal; Jonathan A Javitch; Arthur Christopoulos; Lei Shi; J Robert Lane
Journal:  Biochem Pharmacol       Date:  2018-01-09       Impact factor: 5.858

5.  Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist.

Authors:  Amy E Moritz; R Benjamin Free; Warren S Weiner; Emmanuel O Akano; Disha Gandhi; Ara Abramyan; Thomas M Keck; Marc Ferrer; Xin Hu; Noel Southall; Joseph Steiner; Jeffrey Aubé; Lei Shi; Kevin J Frankowski; David R Sibley
Journal:  J Med Chem       Date:  2020-05-12       Impact factor: 7.446

Review 6.  Harnessing Ion-Binding Sites for GPCR Pharmacology.

Authors:  Barbara Zarzycka; Saheem A Zaidi; Bryan L Roth; Vsevolod Katritch
Journal:  Pharmacol Rev       Date:  2019-10       Impact factor: 25.468

Review 7.  Adaptability of protein structures to enable functional interactions and evolutionary implications.

Authors:  Turkan Haliloglu; Ivet Bahar
Journal:  Curr Opin Struct Biol       Date:  2015-08-06       Impact factor: 6.809

8.  Computational approaches to detect allosteric pathways in transmembrane molecular machines.

Authors:  Sebastian Stolzenberg; Mayako Michino; Michael V LeVine; Harel Weinstein; Lei Shi
Journal:  Biochim Biophys Acta       Date:  2016-01-22

9.  D4 dopamine receptor high-resolution structures enable the discovery of selective agonists.

Authors:  Sheng Wang; Daniel Wacker; Anat Levit; Tao Che; Robin M Betz; John D McCorvy; A J Venkatakrishnan; Xi-Ping Huang; Ron O Dror; Brian K Shoichet; Bryan L Roth
Journal:  Science       Date:  2017-10-20       Impact factor: 47.728

10.  Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D2 and D3 Receptors.

Authors:  Claire L Newton; Martyn D Wood; Philip G Strange
Journal:  PLoS One       Date:  2016-07-05       Impact factor: 3.240
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