Kevin C Choong1, Christopher R McHenry2. 1. Department of Surgery, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA. 2. Department of Surgery, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA. Electronic address: cmchenry@metrohealth.org.
Abstract
BACKGROUND: There has been a dramatic increase in the incidence of thyroid cancer, but it is unclear if this has occurred in patients with toxic nodular goiter (TNG). METHODS: TNG was defined as one or more thyroid nodules in combination with a low serum TSH level. Patients who underwent thyroidectomy for TNG were identified from a prospectively maintained database. The rates of incidental thyroid cancer were compared over the intervals 1990 to 1999, 2000 to 2009, and 2010 to 2014. RESULTS: There was no significant difference in cancer rate between the 3 time periods. Overall, 7 (4.7%) of the 148 patients had thyroid cancer; similarly, 1 (3.2%) of the 31 patients from 1990 to 1999, 3 (4.2%) of 72 patients from 2000 to 2009, and 3 (6.7%) of the 45 patients from 2010 to 2014 (P > .05) had thyroid cancer. CONCLUSIONS: No significant increase in the rate of carcinoma was observed in patients with TNG. As a result, the risk benefit analysis should not change when considering therapeutic options for TNG.
BACKGROUND: There has been a dramatic increase in the incidence of thyroid cancer, but it is unclear if this has occurred in patients with toxic nodular goiter (TNG). METHODS:TNG was defined as one or more thyroid nodules in combination with a low serum TSH level. Patients who underwent thyroidectomy for TNG were identified from a prospectively maintained database. The rates of incidental thyroid cancer were compared over the intervals 1990 to 1999, 2000 to 2009, and 2010 to 2014. RESULTS: There was no significant difference in cancer rate between the 3 time periods. Overall, 7 (4.7%) of the 148 patients had thyroid cancer; similarly, 1 (3.2%) of the 31 patients from 1990 to 1999, 3 (4.2%) of 72 patients from 2000 to 2009, and 3 (6.7%) of the 45 patients from 2010 to 2014 (P > .05) had thyroid cancer. CONCLUSIONS: No significant increase in the rate of carcinoma was observed in patients with TNG. As a result, the risk benefit analysis should not change when considering therapeutic options for TNG.
Authors: Tarek Zaghloul Mohamed; Ahmed Abd El Aal Sultan; Mohamed Tag El-Din; Ahmed A Elfattah Mostafa; Mohammed A Nafea; Abd-Elfattah Kalmoush; Mohammed Shaaban Nassar; Mohamad Adel Abdalgaleel; Ahmed M Hegab; Ayman Helmy Ibrahim; Mohamad Baheeg Journal: Int J Surg Oncol Date: 2022-05-23