| Literature DB >> 25896016 |
Jiayi He1, Jin Gong1, Qiang Ding1, Qinghai Tan1, Ping Han1, Jingmei Liu1, Zhenzhen Zhou1, Wei Tu1, Yujia Xia1, Wei Yan2, Dean Tian3.
Abstract
Liver fibrosis is a worldwide clinical issue. Activation of hepatic stellate cells (HSCs) is the central event during liver fibrosis. We investigated the role of SATB1 in HSC activation and liver fibrogenesis. The results show that SATB1 expression is reduced during HSC activation. Additionally, SATB1 inhibits HSC activation, proliferation, migration, and collagen synthesis. Furthermore, CTGF, a pro-fibrotic agent, is also significantly inhibited by SATB1 through the Ras/Raf-1/MEK/ERK/Ets-1 pathway. In vivo, SATB1 deactivates HSCs and attenuates fibrosis in TAA-induced fibrotic rat livers. These data indicate that SATB1 plays an important role in HSC activation and liver fibrosis.Entities:
Keywords: Hepatic stellate cell; Liver fibrosis; Ras/Raf-1/MEK/ERK/Ets-1; SATB1
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Year: 2015 PMID： 25896016 DOI： 10.1016/j.febslet.2015.04.010
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124