| Literature DB >> 25895986 |
Gaia Sciaranghella1, Cuiwei Wang2, Haihong Hu2, Kathryn Anastos3, Zaher Merhi4, Marek Nowicki5, Frank Z Stanczyk6, Ruth M Greenblatt7, Mardge Cohen8, Elizabeth T Golub9, D Heather Watts10, Galit Alter1, Mary A Young2, Athe M N Tsibris11.
Abstract
Human immunodeficiency virus (HIV) infectivity increases as receptor/coreceptor expression levels increase. We determined peripheral CD4, CCR5, and CXCR4 expression levels in HIV-uninfected women who used depot medroxyprogesterone acetate (DMPA; n = 32), the levonorgestrel-releasing intrauterine device (LNG-IUD; n = 27), oral contraceptive pills (n = 32), or no hormonal contraception (n = 33). The use of LNG-IUD increased the proportion of CD4(+) and CD8(+) T cells that expressed CCR5; increases in the magnitude of T-cell subset CCR5 expression were observed with DMPA and LNG-IUD use (P < .01 for all comparisons). LNG-IUD and, to a lesser extent, DMPA use were associated with increased peripheral T-cell CCR5 expression.Entities:
Keywords: CCR5; CD4; CXCR4; HIV-1; hormonal contraception; levonorgestrel; medroxyprogesterone acetate; oral contraceptive pills; peripheral blood mononuclear cells
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Year: 2015 PMID： 25895986 PMCID： PMC4601918 DOI： 10.1093/infdis/jiv233
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226