Literature DB >> 25895752

Galacto configured N-aminoaziridines: a new type of irreversible inhibitor of β-galactosidases.

Anna Alcaide1, Ana Trapero, Yolanda Pérez, Amadeu Llebaria.   

Abstract

A new type of galactose mimetics has been synthesized following a straightforward synthetic approach based on cyclohexene olefin aziridination reactions directed by hydroxyl substituents. These enantiomerically pure galacto-configured N-aminoaziridines are potent irreversible inhibitors of Aspergillus oryzae and Escherichia coliβ-galactosidases.

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Year:  2015        PMID： 25895752     DOI： 10.1039/c5ob00532a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  4 in total

1.  Side Chain Conformation and Its Influence on Glycosylation Selectivity in Hexo- and Higher Carbon Furanosides.

Authors:  Sameera Siyabalapitiya Arachchige; David Crich
Journal:  J Org Chem       Date:  2021-12-14       Impact factor: 4.354

Review 2.  Recent advances in activity-based probes (ABPs) and affinity-based probes (AfBPs) for profiling of enzymes.

Authors:  Haixiao Fang; Bo Peng; Sing Yee Ong; Qiong Wu; Lin Li; Shao Q Yao
Journal:  Chem Sci       Date:  2021-05-18       Impact factor: 9.825

3.  Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes.

Authors:  Jianbing Jiang; Chi-Lin Kuo; Liang Wu; Christian Franke; Wouter W Kallemeijn; Bogdan I Florea; Eline van Meel; Gijsbert A van der Marel; Jeroen D C Codée; Rolf G Boot; Gideon J Davies; Herman S Overkleeft; Johannes M F G Aerts
Journal:  ACS Cent Sci       Date:  2016-04-26       Impact factor: 14.553

4.  Direct Stereoselective Aziridination of Cyclohexenols with 3-Amino-2-(trifluoromethyl)quinazolin-4(3H)-one in the Synthesis of Cyclitol Aziridine Glycosidase Inhibitors.

Authors:  Marta Artola; Shirley Wouters; Sybrin P Schröder; Casper de Boer; Yurong Chen; Rita Petracca; Adrianus M C H van den Nieuwendijk; Johannes M F G Aerts; Gijsbert A van der Marel; Jeroen D C Codée; Herman S Overkleeft
Journal:  European J Org Chem       Date:  2019-01-11
  4 in total

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