OBJECTIVE: To study the effect of estrogen-like effective part of Selaginella tarmariscina on bone metabolism in ovariectomized rats. METHODS: Wistar female rats were carried out the castration to remove both ovaries (except the sham group), in order to establish the rat model of postmenopausal osteoporosis. The estrogen-like effective part of Selaginella tarmariscina was administered after surgery to therapeutic intervention. After 40 weeks of administration, the rats were sacrificed, the right femur bone mineral density (BMD) and bone biomechanical indicators were detected. Serum alkaline phosphatase (ALP), calcium (Ca), phosphorus (P), serum estradiol (E2), parathyroid hormone (PTH), tartrate-resistant acid phosphatase (TRAP), osteocalcin (BGP), calcitonin (CT), I procollagen carboxy-terminal propeptide (PICP) and other biochemical markers were determined. RESULTS: Compared with the model group, Selaginella tarmariscina effective parts increased the level of serum E2 and CT (P < 0.05), reduced serum ALP, TRAP, BGP, PTH and PICP level (P < 0.05), improved stiffness (P < 0.05), femur bone mineral density, max-load, max-disp, break-disp, energy-absorption and elastic (P > 0.05). CONCLUSION: The estrogen-like effective parts of Selaginella tarmariscina has a certain intervention effect on postmenopausal osteoporosis.
OBJECTIVE: To study the effect of estrogen-like effective part of Selaginella tarmariscina on bone metabolism in ovariectomized rats. METHODS: Wistar female rats were carried out the castration to remove both ovaries (except the sham group), in order to establish the rat model of postmenopausal osteoporosis. The estrogen-like effective part of Selaginella tarmariscina was administered after surgery to therapeutic intervention. After 40 weeks of administration, the rats were sacrificed, the right femur bone mineral density (BMD) and bone biomechanical indicators were detected. Serum alkaline phosphatase (ALP), calcium (Ca), phosphorus (P), serum estradiol (E2), parathyroid hormone (PTH), tartrate-resistant acid phosphatase (TRAP), osteocalcin (BGP), calcitonin (CT), I procollagen carboxy-terminal propeptide (PICP) and other biochemical markers were determined. RESULTS: Compared with the model group, Selaginella tarmariscina effective parts increased the level of serum E2 and CT (P < 0.05), reduced serum ALP, TRAP, BGP, PTH and PICP level (P < 0.05), improved stiffness (P < 0.05), femur bone mineral density, max-load, max-disp, break-disp, energy-absorption and elastic (P > 0.05). CONCLUSION: The estrogen-like effective parts of Selaginella tarmariscina has a certain intervention effect on postmenopausal osteoporosis.