| Literature DB >> 25894778 |
T V Tyrinova1, O Yu Leplina, M A Tikhonova, S V Mishinov, V V Stupak, A A Ostanin, E R Chernykh.
Abstract
We compared migration activities of IFN-α- and IL-4-induced dendritic cells (IFN-DC and IL4-DC) generated from blood monocytes of healthy donors and analyzed migration activity of IFN-DC from patients with brain tumors. In the presence of CCL19 chemokine, donor IFN-DC exhibited higher migration activity than IL4-DC, the expression of chemokine CCR7-receptor being similar in the two cell types. IFN-DC of patients with malignant gliomas were characterized by low chemotaxis in response to CCL19 and CCL21 stimulation despite a trend to higher expression of CCR7 in comparison with donor IFN-DC.Entities:
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Year: 2015 PMID： 25894778 DOI： 10.1007/s10517-015-2862-4
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804