Literature DB >> 25894172

Dermal tophus: a complication of gout in a kidney transplant recipient.

Ebru Hatice Ayvazoglu Soy1, Emre Karakaya, Arzu Karatas Togral, Aydincan Akdur, Gokhan Moray, Mehmet Haberal.   

Abstract

Gout is a chronic metabolic disease caused by disturbance of purine metabolism that leads to hyperuricemia. Hyperuricemia prevalence after renal transplant is reported as 19% to 84% in different studies. Tophaceous gout in renal transplant recipients is a consequence of increased hyperuricemia. Although tophus formation in skin and soft tissues is an indicator of chronic gout (also referred to as tophaceous gout), tophi may be the first sign of gout. In this study, we report a case of a 62-year-old male renal transplant recipient who had tophi as the first clinical sign of gout. After confirming gout diagnosis, cyclosporine was changed to sirolimus, and allopurinol was added to therapy to decrease uric acid levels. In conclusion, hyperuricemia is a common complication in renal transplant recipients. Presentation might be atypical, and diagnosis can be challenging.

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Year:  2015        PMID: 25894172     DOI: 10.6002/ect.mesot2014.p112

Source DB:  PubMed          Journal:  Exp Clin Transplant        ISSN: 1304-0855            Impact factor:   0.945


  1 in total

1.  Metabolic characteristics and renal dysfunction in 65 patients with tophi prior to gout.

Authors:  Chuan-Chin Lu; Shyi-Kuen Wu; Wei-Sheng Chung; Liang-Hung Lin; Ta-Wei Hung; Chih-Jung Yeh
Journal:  Clin Rheumatol       Date:  2017-05-10       Impact factor: 2.980

  1 in total

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