Literature DB >> 25892507

A review of fluorescent ligands for studying 5-HT3 receptors.

Martin Lochner1, Andrew J Thompson2.   

Abstract

The use of fluorescence is a valuable and increasingly accessible means of probing the pharmacology and physiology of cells and their receptors. To date, the use of fluorescence-based methods for 5-HT3 receptor research has been quite limited and, although a variety of approaches have been described, these are broadly distributed throughout the literature. In this review we condense these findings into a single, accessible source of reference with the hope of promoting the use of these valuable molecular probes. This article is part of the Special Issue entitled 'Fluorescent Tools in Neuropharmacology'.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  5-HT(3) receptor; Flow cytometry; Fluorescence polarisation; Fluorescent ligand; Imaging; Synthesis

Mesh:

Substances:

Year:  2015        PMID: 25892507     DOI: 10.1016/j.neuropharm.2015.04.002

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN: 0028-3908            Impact factor:   5.250


  3 in total

1.  The muscarinic antagonists scopolamine and atropine are competitive antagonists at 5-HT3 receptors.

Authors:  Martin Lochner; Andrew J Thompson
Journal:  Neuropharmacology       Date:  2016-04-22       Impact factor: 5.250

2.  The binding orientation of epibatidine at α7 nACh receptors.

Authors:  Andrew J Thompson; Simon Metzger; Martin Lochner; Marc-David Ruepp
Journal:  Neuropharmacology       Date:  2017-01-12       Impact factor: 5.250

Review 3.  Drug Discovery on Natural Products: From Ion Channels to nAChRs, from Nature to Libraries, from Analytics to Assays.

Authors:  Reka A Otvos; Kristina B M Still; Govert W Somsen; August B Smit; Jeroen Kool
Journal:  SLAS Discov       Date:  2019-01-25       Impact factor: 3.341

  3 in total

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