Guangyi Li1, Qiujian Zheng2, Euphemie Landao-Bassonga3, Tak S Cheng3, Nathan J Pavlos3, Yuanchen Ma2, Changqing Zhang4, Ming H Zheng5. 1. Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China; Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Perth, Australia. 2. Division of Orthopaedic Surgery, Guangdong General Hospital, Guangzhou, China. 3. Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Perth, Australia. 4. Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. Electronic address: zhangcq@sjtu.edu.cn. 5. Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Perth, Australia. Electronic address: minghao.zheng@uwa.edu.au.
Abstract
INTRODUCTION: Age and gender have been reported to have a remarkable impact on bone homeostasis. However, subchondral bone, which plays a pivotal role in the initiation and progression of OA, has been poorly investigated. This study was to investigate age- and gender-related changes of microarchitecture and bone remodeling in subchondral bone in OA. METHODS: Subchondral trabecular bone (STB) and deeper trabecular bone (DTB) specimens were extracted in the load-bearing region of femoral heads from 110 patients with OA. Micro-CT and histomorphometry were performed to analyze microarchitectural and bone remodeling changes of all specimens. RESULTS: Compared to DTB, STB showed more sclerotic microarchitecture, more active bone remodeling and higher frequency of bone cysts. There were no gender differences for both microarchitecture and bone remodeling in STB. However, gender differences were found in DTB, with thinner Tb.Th, higher Tb.N, higher OS/BV and ES/BV in males. In both STB and DTB, no correlation between microarchitecture and age was found in both genders. However, bone remodeling of STB increased significantly with age in males, while bone remodeling of DTB increased significantly with age in females. No age or gender preference was found in subchondral bone cyst (SBC) frequency. The cyst volume fraction was correlated with neither age nor gender. CONCLUSIONS: There were differences in microarchitecture and bone remodeling between STB and DTB, which may be due to the distinct biomechanical and biochemical functions of these two bone structures in maintaining joint homeostasis. OA changed the normal age- and gender-dependence of bone homeostasis in joints, in a site-specific manner.
INTRODUCTION: Age and gender have been reported to have a remarkable impact on bone homeostasis. However, subchondral bone, which plays a pivotal role in the initiation and progression of OA, has been poorly investigated. This study was to investigate age- and gender-related changes of microarchitecture and bone remodeling in subchondral bone in OA. METHODS: Subchondral trabecular bone (STB) and deeper trabecular bone (DTB) specimens were extracted in the load-bearing region of femoral heads from 110 patients with OA. Micro-CT and histomorphometry were performed to analyze microarchitectural and bone remodeling changes of all specimens. RESULTS: Compared to DTB, STB showed more sclerotic microarchitecture, more active bone remodeling and higher frequency of bone cysts. There were no gender differences for both microarchitecture and bone remodeling in STB. However, gender differences were found in DTB, with thinner Tb.Th, higher Tb.N, higher OS/BV and ES/BV in males. In both STB and DTB, no correlation between microarchitecture and age was found in both genders. However, bone remodeling of STB increased significantly with age in males, while bone remodeling of DTB increased significantly with age in females. No age or gender preference was found in subchondral bone cyst (SBC) frequency. The cyst volume fraction was correlated with neither age nor gender. CONCLUSIONS: There were differences in microarchitecture and bone remodeling between STB and DTB, which may be due to the distinct biomechanical and biochemical functions of these two bone structures in maintaining joint homeostasis. OA changed the normal age- and gender-dependence of bone homeostasis in joints, in a site-specific manner.
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Authors: Lianzhi Chen; Felix Yao; Tao Wang; Guangyi Li; Peilin Chen; Max Bulsara; Jessica Jun Yi Zheng; Euphemie Landao-Bassonga; Marty Firth; Praveen Vasantharao; Yigang Huang; Michelle Lorimer; Stephen Graves; Junjie Gao; Richard Carey-Smith; John Papadimitriou; Changqing Zhang; David Wood; Christopher Jones; Minghao Zheng Journal: Ann Rheum Dis Date: 2020-04-08 Impact factor: 19.103