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Literature DB >> 25892397

Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization.

Qian-Rong Qi¹, Xu-Yu Zhao, Ru-Juan Zuo, Tong-Song Wang, Xiao-Wei Gu, Ji-Long Liu, Zeng-Ming Yang.

Abstract

Polyploid decidual cells are specifically differentiated cells during mouse uterine decidualization. However, little is known about the regulatory mechanism and physiological significance of polyploidization in pregnancy. Here we report a novel role of E2F8 in the polyploidization of decidual cells in mice. E2F8 is highly expressed in decidual cells and regulated by progesterone through HB-EGF/EGFR/ERK/STAT3 signaling pathway. E2F8 transcriptionally suppresses CDK1, thus triggering the polyploidization of decidual cells. E2F8-mediated polyploidization is a response to stresses which are accompanied by decidualization. Interestingly, polyploidization is not detected during human decidualization with the down-regulation of E2F8, indicating differential expression of E2F8 may lead to the difference of decidual cell polyploidization between mice and humans.

Entities: Chemical Gene Species

Keywords: CDK1, cyclin-dependent kinase 1; CPT, Camptothecin; E2, estrogen; E2F8; MKC, megakaryocyte; P4, progesterone; PA, Purvalanol A; TGC, Trophoblast giant cell.; decidualization; polyploidization

Mesh：

Substances：

Year: 2015 PMID： 25892397 PMCID： PMC4614110 DOI： 10.1080/15384101.2015.1033593

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

47 in total

1. The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy.

Authors: Bart Westendorp; Jennifer L Major; Moni Nader; Maysoon Salih; Frans H H Leenen; Balwant S Tuana
Journal: FASEB J Date: 2012-03-07 Impact factor: 5.191

2. Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice.

Authors: Wei Lei; Xu-Hui Feng; Wen-Bo Deng; Hua Ni; Zhi-Rong Zhang; Bo Jia; Xin-Ling Yang; Tong-Song Wang; Ji-Long Liu; Ren-Wei Su; Xiao-Huan Liang; Qian-Rong Qi; Zeng-Ming Yang
Journal: J Biol Chem Date: 2012-03-08 Impact factor: 5.157

3. Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.

Authors: Tinghui Hu; Seda Ghazaryan; Chandler Sy; Charles Wiedmeyer; Victor Chang; Lizhao Wu
Journal: Blood Date: 2012-03-14 Impact factor: 22.113

4. The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence.

Authors: Ozlem Aksoy; Agustin Chicas; Tianying Zeng; Zhen Zhao; Mila McCurrach; Xiaowo Wang; Scott W Lowe
Journal: Genes Dev Date: 2012-07-15 Impact factor: 11.361

5. Atypical E2F repressors and activators coordinate placental development.

Authors: Madhu M Ouseph; Jing Li; Hui-Zi Chen; Thierry Pécot; Pamela Wenzel; John C Thompson; Grant Comstock; Veda Chokshi; Morgan Byrne; Braxton Forde; Jean-Leon Chong; Kun Huang; Raghu Machiraju; Alain de Bruin; Gustavo Leone
Journal: Dev Cell Date: 2012-04-17 Impact factor: 12.270

6. E2F8 is essential for polyploidization in mammalian cells.

Authors: Shusil K Pandit; Bart Westendorp; Sathidpak Nantasanti; Elsbeth van Liere; Peter C J Tooten; Peter W A Cornelissen; Mathilda J M Toussaint; Wouter H Lamers; Alain de Bruin
Journal: Nat Cell Biol Date: 2012-10-14 Impact factor: 28.824

7. E2F7 can regulate proliferation, differentiation, and apoptotic responses in human keratinocytes: implications for cutaneous squamous cell carcinoma formation.

Authors: Liliana Endo-Munoz; Alison Dahler; Ngari Teakle; Danny Rickwood; Mehlika Hazar-Rethinam; Ibtissam Abdul-Jabbar; Scott Sommerville; Ian Dickinson; Pritinder Kaur; Sophie Paquet-Fifield; Nicholas Saunders
Journal: Cancer Res Date: 2009-02-17 Impact factor: 12.701

8. Leukemia inhibitory factor enhances endometrial stromal cell decidualization in humans and mice.

Authors: Lorraine Lin Shuya; Ellen Melaleuca Menkhorst; Joanne Yap; Priscilla Li; Natalie Lane; Evdokia Dimitriadis
Journal: PLoS One Date: 2011-09-23 Impact factor: 3.240

9. E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1.

Authors: Bart G M W Weijts; Walbert J Bakker; Peter W A Cornelissen; Kuo-Hsuan Liang; Frank H Schaftenaar; Bart Westendorp; Charlotte A C M T de Wolf; Maya Paciejewska; Colinda L G J Scheele; Lindsey Kent; Gustavo Leone; Stefan Schulte-Merker; Alain de Bruin
Journal: EMBO J Date: 2012-08-17 Impact factor: 11.598

10. Canonical and atypical E2Fs regulate the mammalian endocycle.

Authors: Hui-Zi Chen; Madhu M Ouseph; Jing Li; Thierry Pécot; Veda Chokshi; Lindsey Kent; Sooin Bae; Morgan Byrne; Camille Duran; Grant Comstock; Prashant Trikha; Markus Mair; Shantibhusan Senapati; Chelsea K Martin; Sagar Gandhi; Nicholas Wilson; Bin Liu; Yi-Wen Huang; John C Thompson; Sundaresan Raman; Shantanu Singh; Marcelo Leone; Raghu Machiraju; Kun Huang; Xiaokui Mo; Soledad Fernandez; Ilona Kalaszczynska; Debra J Wolgemuth; Piotr Sicinski; Tim Huang; Victor Jin; Gustavo Leone
Journal: Nat Cell Biol Date: 2012-10-14 Impact factor: 28.824

18 in total

Review 1. Uterine Glands: Developmental Biology and Functional Roles in Pregnancy.

Authors: Andrew M Kelleher; Francesco J DeMayo; Thomas E Spencer
Journal: Endocr Rev Date: 2019-10-01 Impact factor: 19.871

2. Developmental and hormonal regulation of ubiquitin-like with plant homeodomain and really interesting new gene finger domains 1 gene expression in ovarian granulosa and theca cells of cattle.

Authors: Maria Chiara Perego; Breanne C Morrell; Lingna Zhang; Luis F Schütz; Leon J Spicer
Journal: J Anim Sci Date: 2020-07-01 Impact factor: 3.159

3. NR4A1 Affects Endometrial Receptivity by Participating in Mesenchymal-Epithelial Transition of Endometrial Stromal Cells.

Authors: Xiangjing Tang; Haishan Zheng; Hongxia Xu; Mei Wang; Xiaomin Kang; Ze Wu
Journal: Reprod Sci Date: 2021-11-12 Impact factor: 3.060

Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization.

1. The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy.

2. Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice.

3. Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.

4. The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence.

5. Atypical E2F repressors and activators coordinate placental development.

6. E2F8 is essential for polyploidization in mammalian cells.

7. E2F7 can regulate proliferation, differentiation, and apoptotic responses in human keratinocytes: implications for cutaneous squamous cell carcinoma formation.

8. Leukemia inhibitory factor enhances endometrial stromal cell decidualization in humans and mice.

9. E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1.

10. Canonical and atypical E2Fs regulate the mammalian endocycle.

Review 1. Uterine Glands: Developmental Biology and Functional Roles in Pregnancy.

2. Developmental and hormonal regulation of ubiquitin-like with plant homeodomain and really interesting new gene finger domains 1 gene expression in ovarian granulosa and theca cells of cattle.

3. NR4A1 Affects Endometrial Receptivity by Participating in Mesenchymal-Epithelial Transition of Endometrial Stromal Cells.

Review 4. Polyploidy in liver development, homeostasis and disease.

5. AMPK is required for uterine receptivity and normal responses to steroid hormones.

6. Osteopontin facilitates invasion in human trophoblastic cells via promoting matrix metalloproteinase-9 in vitro.

7. Control of regional decidualization in implantation: Role of FoxM1 downstream of Hoxa10 and cyclin D3.

Review 8. E2F8 is a Potential Therapeutic Target for Hepatocellular Carcinoma.

9. Enhanced Stromal Cell CBS-H2S Production Promotes Estrogen-Stimulated Human Endometrial Angiogenesis.

10. The high concentration of progesterone is harmful for endometrial receptivity and decidualization.