Literature DB >> 25892205

Tumor-targeted Delivery of Anti-microRNA for Cancer Therapy: pHLIP is Key.

Ernst Wagner1.   

Abstract

pHLIP opens the door to the cell: An improved cytosolic transfer of anti-microRNAs (anti-miRs) against onco-miRs paves the way for future cancer therapies. The employed anti-miR-peptide conjugates are based on peptide nucleic acids (PNAs), which are connected with the membrane translocation peptide pHLIP through a disulfide bond. The PNAs are thus transferred into the cell and released by the cleavage of the S-S bond.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  RNA; membranes; microRNA; peptide nucleic acids; targeted delivery

Mesh：

Substances：

Year:  2015        PMID： 25892205     DOI： 10.1002/anie.201502146

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  8 in total

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2.  Application of novel targeted molecular imaging probes in the early diagnosis of upper urinary tract epithelial carcinoma.

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Journal:  Oncol Lett       Date:  2018-09-11       Impact factor: 2.967

3.  Identification of Prognosis Associated microRNAs in HNSCC Subtypes Based on TCGA Dataset.

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Review 4.  Non-coding RNAs as potential biomarkers and therapeutic targets in polycystic kidney disease.

Authors:  Qi Zheng; Glen Reid; Michael R Eccles; Cherie Stayner
Journal:  Front Physiol       Date:  2022-09-20       Impact factor: 4.755

5.  Simultaneous visualization of the subfemtomolar expression of microRNA and microRNA target gene using HILO microscopy.

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Journal:  Chem Sci       Date:  2017-07-31       Impact factor: 9.825

6.  Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response.

Authors:  Mahnaz Sahraei; Balkrishna Chaube; Yuting Liu; Jonathan Sun; Alanna Kaplan; Nathan L Price; Wen Ding; Stanley Oyaghire; Rolando García-Milian; Sameet Mehta; Yana K Reshetnyak; Raman Bahal; Paolo Fiorina; Peter M Glazer; David L Rimm; Carlos Fernández-Hernando; Yajaira Suárez
Journal:  J Clin Invest       Date:  2019-12-02       Impact factor: 14.808

Review 7.  Nucleic Acid-Based Approaches for Tumor Therapy.

Authors:  Simone Hager; Frederic Julien Fittler; Ernst Wagner; Matthias Bros
Journal:  Cells       Date:  2020-09-09       Impact factor: 6.600

Review 8.  Targeting the Hypoxic and Acidic Tumor Microenvironment with pH-Sensitive Peptides.

Authors:  Nayanthara U Dharmaratne; Alanna R Kaplan; Peter M Glazer
Journal:  Cells       Date:  2021-03-04       Impact factor: 6.600
  8 in total

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