| Literature DB >> 25891970 |
Thomas O Ronson1, Martin H H Voelkel, Richard J K Taylor, Ian J S Fairlamb.
Abstract
The stereoselective synthesis of a challenging macrocyclic polyene scaffold, containing a sensitive vinyl ether motif, has been accomplished using O,C-dilithiation/selective C-alkylation, Pd-catalysed etherification and Wittig reactions as key steps. An end-game macrocyclisation strategy employed a regio- and stereoselective Stille cross-coupling using Pd(Br)(N-Succ)(AsPh3)2 (AsCat) as the precatalyst.Entities:
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Year: 2015 PMID： 25891970 DOI： 10.1039/c5cc02091c
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222