| Literature DB >> 25891915 |
Alyssa E Barry, Andreea Waltmann, Cristian Koepfli, Celine Barnadas, Ivo Mueller.
Abstract
Population genetic analysis of malaria parasites has the power to reveal key insights into malaria epidemiology and transmission dynamics with the potential to deliver tools to support control and elimination efforts. Analyses of parasite genetic diversity have suggested that Plasmodium vivax populations are more genetically diverse and less structured than those of Plasmodium falciparum indicating that P. vivax may be a more ancient parasite of humans and/or less susceptible to population bottlenecks, as well as more efficient at disseminating its genes. These population genetic insights into P. vivax transmission dynamics provide an explanation for its relative resilience to control efforts. Here, we describe current knowledge on P. vivax population genetic structure, its relevance to understanding transmission patterns and relapse and how this information can inform malaria control and elimination programmes.Entities:
Keywords: Control,; Elimination; Genetic diversity,; Genetics,; Genomics,; Linkage disequilibrium,; Malaria,; Microsatellites,; Mitochondrial DNA,; Plasmodium vivax,; Population structure,; Relapse,; Single nucleotide polymorphisms,; Transmission,
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Year: 2015 PMID： 25891915 PMCID： PMC4455355 DOI： 10.1179/2047773215Y.0000000012
Source DB: PubMed Journal: Pathog Glob Health ISSN： 2047-7724 Impact factor: 2.894