M L A Landsmeer1, J Runhaar2, Y E Henrotin3, M Middelkoop van4, E H G Oei5, D Vroegindeweij6, M Reijman7, G J V M van Osch8, B W Koes9, P J E Bindels10, S M A Bierma-Zeinstra11. 1. Department of General Practice, Erasmus MC, University Medical Center Rotterdam, The Netherlands. Electronic address: m.landsmeer@erasmusmc.nl. 2. Department of General Practice, Erasmus MC, University Medical Center Rotterdam, The Netherlands. Electronic address: j.runhaar@erasmusmc.nl. 3. Bone and Cartilage Research Unit, University of Liège, Sart Tilman, 4000 Liège, Belgium; Physical Therapy and Rehabilitation Department, Princess Paola Hospital, Marche-en-Famenne, Belgium. Electronic address: yhenrotin@ulg.ac.be. 4. Department of General Practice, Erasmus MC, University Medical Center Rotterdam, The Netherlands. Electronic address: m.vanmiddelkoop@erasmusmc.nl. 5. Department of Radiology, Erasmus MC, University Medical Center Rotterdam, The Netherlands. Electronic address: e.oei@erasmusmc.nl. 6. Department of Radiology, Maasstad Hospital, Rotterdam, The Netherlands. Electronic address: vroegindeweijd@maasstadziekenhuis.nl. 7. Department of Orthopaedics, Erasmus MC, University Medical Center Rotterdam, The Netherlands. Electronic address: m.reijman@erasmusmc.nl. 8. Department of Orthopaedics, Erasmus MC, University Medical Center Rotterdam, The Netherlands. Electronic address: g.vanosch@erasmusmc.nl. 9. Department of General Practice, Erasmus MC, University Medical Center Rotterdam, The Netherlands. Electronic address: b.koes@erasmusmc.nl. 10. Department of General Practice, Erasmus MC, University Medical Center Rotterdam, The Netherlands. Electronic address: p.bindels@erasmusmc.nl. 11. Department of General Practice, Erasmus MC, University Medical Center Rotterdam, The Netherlands; Department of Orthopaedics, Erasmus MC, University Medical Center Rotterdam, The Netherlands. Electronic address: s.bierma-zeinstra@erasmusmc.nl.
Abstract
OBJECTIVE: To investigate the association between urinary biomarker Coll2-1NO2 (uColl2-1NO2) and incident knee OA after 2.5 years follow-up in middle-aged overweight and obese women at high risk for knee osteoarthritis (OA). DESIGN: Data were used from PROOF, a randomized controlled trial with 2.5 years follow-up evaluating the preventive effects of a diet and exercise program and oral glucosamine sulphate (double blind and placebo controlled), on development of incident knee OA in women with body mass index ≥ 27 kg/m(2) without signs of knee OA at baseline. Baseline and 2.5 years uColl2-1NO2 concentrations were assessed with enzyme-linked immunosorbent assay (ELISA). Primary outcome measure was incidence of knee OA in one or both knees, defined as incidence of either Kellgren & Lawrence grade ≥2, joint space narrowing of ≥1.0 mm or knee OA according to the combined clinical and radiographic ACR-criteria. We used binary logistic regression for the association analyses. RESULTS:254 women were available for analyses. At 2.5 years follow-up, incident knee OA was present in 72 of 254 women (28.3%). An inversed association was found between baseline uColl2-1NO2 and incident knee OA at 2.5 years (OR 0.74, 95% CI 0.55-0.99). The concentration at 2.5 years and the change in concentration over 2.5 years did not show significant associations with the outcome. CONCLUSIONS: In overweight and obese middle-aged women, not higher but lower baseline uColl2-1NO2 concentration was significantly associated with an increased risk for incident knee OA. This interesting but counterintuitive outcome makes further validation of this biomarker warranted.
RCT Entities:
OBJECTIVE: To investigate the association between urinary biomarker Coll2-1NO2 (uColl2-1NO2) and incident knee OA after 2.5 years follow-up in middle-aged overweight and obesewomen at high risk for knee osteoarthritis (OA). DESIGN: Data were used from PROOF, a randomized controlled trial with 2.5 years follow-up evaluating the preventive effects of a diet and exercise program and oral glucosamine sulphate (double blind and placebo controlled), on development of incident knee OA in women with body mass index ≥ 27 kg/m(2) without signs of knee OA at baseline. Baseline and 2.5 years uColl2-1NO2 concentrations were assessed with enzyme-linked immunosorbent assay (ELISA). Primary outcome measure was incidence of knee OA in one or both knees, defined as incidence of either Kellgren & Lawrence grade ≥2, joint space narrowing of ≥1.0 mm or knee OA according to the combined clinical and radiographic ACR-criteria. We used binary logistic regression for the association analyses. RESULTS: 254 women were available for analyses. At 2.5 years follow-up, incident knee OA was present in 72 of 254 women (28.3%). An inversed association was found between baseline uColl2-1NO2 and incident knee OA at 2.5 years (OR 0.74, 95% CI 0.55-0.99). The concentration at 2.5 years and the change in concentration over 2.5 years did not show significant associations with the outcome. CONCLUSIONS: In overweight and obese middle-aged women, not higher but lower baseline uColl2-1NO2 concentration was significantly associated with an increased risk for incident knee OA. This interesting but counterintuitive outcome makes further validation of this biomarker warranted.
Authors: Huub M de Visser; Christelle Sanchez; Simon C Mastbergen; Floris P J G Lafeber; Yves E Henrotin; Harrie Weinans Journal: Cartilage Date: 2018-01-24 Impact factor: 4.634