Himani Pathak1, Sujata Mohanty2, Aadithya B Urs3, Jitender Dabas4. 1. Postgraduate Third-year Student, Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, India. Electronic address: drhimanipathak@gmail.com. 2. Professor and Head, Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, India. 3. Professor and Head, Department of Oral Pathology and Microbiology, Maulana Azad Institute of Dental Sciences, New Delhi, India. 4. Senior Resident, Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, India.
Abstract
PURPOSE: One of the preferred treatment options for oral mucosal lesions (eg, leukoplakia and lichen planus) is excision, with or without the use of a coverage agent. Platelet-rich fibrin (PRF) membranes are popular fibrin scaffolds with entrapped platelets that release various growth factors and cytokines to support and enhance wound healing. The aim of the present report was to describe the technique, postoperative wound care, and clinical results of PRF membrane grafting after excision of superficial potentially malignant oral lesions. MATERIALS AND METHODS: Autologous PRF membrane was fabricated and grafted over 26 wounds created by excision of small, superficial, potentially malignant lesions of oral mucosa (or fiberotomy in cases of oral submucous fibrosis) and assessed clinically at 7, 15, 30, and 60 days. RESULTS: Healing was satisfactory in all cases, with minimal and manageable complication at 1 site. CONCLUSION: The results of the present study suggest that PRF membrane is a successful coverage agent that aids in the healing of superficial oral mucosal wounds. Additional comparative studies are required to establish its efficacy compared with that of other agents.
PURPOSE: One of the preferred treatment options for oral mucosal lesions (eg, leukoplakia and lichen planus) is excision, with or without the use of a coverage agent. Platelet-rich fibrin (PRF) membranes are popular fibrin scaffolds with entrapped platelets that release various growth factors and cytokines to support and enhance wound healing. The aim of the present report was to describe the technique, postoperative wound care, and clinical results of PRF membrane grafting after excision of superficial potentially malignant oral lesions. MATERIALS AND METHODS: Autologous PRF membrane was fabricated and grafted over 26 wounds created by excision of small, superficial, potentially malignant lesions of oral mucosa (or fiberotomy in cases of oral submucous fibrosis) and assessed clinically at 7, 15, 30, and 60 days. RESULTS: Healing was satisfactory in all cases, with minimal and manageable complication at 1 site. CONCLUSION: The results of the present study suggest that PRF membrane is a successful coverage agent that aids in the healing of superficial oral mucosal wounds. Additional comparative studies are required to establish its efficacy compared with that of other agents.
Authors: Carlos Fernando de Almeida Barros Mourão; Mônica Diuana Calasans-Maia; Rafael Coutinho de Mello Machado; Rodrigo Figueiredo de Brito Resende; Gutemberg Gomes Alves Journal: Oral Maxillofac Surg Date: 2018-06-26
Authors: Brittany N Allen; Qi Wang; Yassine Filali; Kristan S Worthington; Deborah S F Kacmarynski Journal: Tissue Eng Part B Rev Date: 2022-01-24 Impact factor: 7.376