Literature DB >> 25890222

Genomic profiling guides the choice of molecular targeted therapy of pancreatic cancer.

Thomas S Frank1, Xiaotian Sun2, Yuqing Zhang3, Jingxuan Yang4, William E Fisher5, Marie-Claude Gingras6, Min Li7.   

Abstract

Pancreatic cancer has the worst five-year survival rate of all malignancies due to its aggressive progression and resistance to therapy. Current therapies are limited to gemcitabine-based chemotherapeutics, surgery, and radiation. The current trend toward "personalized genomic medicine" has the potential to improve the treatment options for pancreatic cancer. Gene identification and genetic alterations like single nucleotide polymorphisms and mutations will allow physicians to predict the efficacy and toxicity of drugs, which could help diagnose pancreatic cancer, guide neoadjuvant or adjuvant treatment, and evaluate patients' prognosis. This article reviews the multifaceted roles of genomics and pharmacogenomics in pancreatic cancer.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Gene therapy; Genomic profiling; Mutations; Pancreatic cancer; Pharmacogenomics; SLC39A4 (ZIP4)

Mesh：

Substances：

Year:  2015        PMID： 25890222      PMCID： PMC4451193          DOI： 10.1016/j.canlet.2015.04.009

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  76 in total

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Journal:  Cancer Biol Ther       Date:  2012-03-01       Impact factor: 4.742

2.  Pdx1 expression in pancreatic precursor lesions and neoplasms.

Authors:  Jason Y Park; Seung-Mo Hong; David S Klimstra; Michael G Goggins; Anirban Maitra; Ralph H Hruban
Journal:  Appl Immunohistochem Mol Morphol       Date:  2011-10

3.  TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression.

Authors:  M Seux; S Peuget; M P Montero; C Siret; V Rigot; P Clerc; V Gigoux; E Pellegrino; L Pouyet; P N'Guessan; S Garcia; M Dufresne; J L Iovanna; A Carrier; F André; N J Dusetti
Journal:  Oncogene       Date:  2011-02-21       Impact factor: 9.867

4.  Distant metastasis in p16-positive oropharyngeal squamous cell carcinoma: a critical analysis of patterns and outcomes.

Authors:  P Sinha; W T Thorstad; B Nussenbaum; B H Haughey; D R Adkins; D Kallogjeri; J S Lewis
Journal:  Oral Oncol       Date:  2013-11-06       Impact factor: 5.337

5.  Methylation of the SPARC gene promoter and its clinical implication in pancreatic cancer.

Authors:  Jun Gao; Jian Song; Haojie Huang; Zhaoshen Li; Yiqi Du; Jia Cao; Minghui Li; Shunli Lv; Han Lin; Yanfang Gong
Journal:  J Exp Clin Cancer Res       Date:  2010-03-26

6.  Immunohistochemically detected expression of 3 major genes (CDKN2A/p16, TP53, and SMAD4/DPC4) strongly predicts survival in patients with resectable pancreatic cancer.

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Journal:  Ann Surg       Date:  2013-08       Impact factor: 12.969

7.  Increased PDX-1 expression is associated with outcome in patients with pancreatic cancer.

Authors:  Masayuki Koizumi; Ryuichiro Doi; Eiji Toyoda; Toshihiko Masui; Sidhartha S Tulachan; Yoshiya Kawaguchi; Koji Fujimoto; George K Gittes; Masayuki Imamura
Journal:  Surgery       Date:  2003-08       Impact factor: 3.982

8.  Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines.

Authors:  J R Mackey; R S Mani; M Selner; D Mowles; J D Young; J A Belt; C R Crawford; C E Cass
Journal:  Cancer Res       Date:  1998-10-01       Impact factor: 12.701

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Authors:  Han Chung Chong; Chek Kun Tan; Royston-Luke Huang; Nguan Soon Tan
Journal:  J Oncol       Date:  2012-02-09       Impact factor: 4.375

10.  Exome sequencing identifies nonsegregating nonsense ATM and PALB2 variants in familial pancreatic cancer.

Authors:  Robert C Grant; Wigdan Al-Sukhni; Ayelet E Borgida; Spring Holter; Zaheer S Kanji; Treasa McPherson; Emily Whelan; Stefano Serra; Quang M Trinh; Vanya Peltekova; Lincoln D Stein; John D McPherson; Steven Gallinger
Journal:  Hum Genomics       Date:  2013-04-05       Impact factor: 4.639
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  8 in total

1.  Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer.

Authors:  Lebaron C Agostini; Grace A McCarthy; Aditi Jain; Saswati N Chand; AnnJosette Ramirez; Avinoam Nevler; Joseph Cozzitorto; Christopher W Schultz; Cinthya Yabar Lowder; Kate M Smith; Ian D Waddell; Maria Raitses-Gurevich; Chani Stossel; Yulia Glick Gorman; Dikla Atias; Charles J Yeo; Jordan M Winter; Kenneth P Olive; Talia Golan; Michael J Pishvaian; Donald Ogilvie; Dominic I James; Allan M Jordan; Jonathan R Brody
Journal:  Cancer Res       Date:  2019-07-04       Impact factor: 12.701

2.  Repurposing metformin, simvastatin and digoxin as a combination for targeted therapy for pancreatic ductal adenocarcinoma.

Authors:  Shi-He Liu; Juehua Yu; Justin F Creeden; Jeffrey M Sutton; Stephen Markowiak; Robbi Sanchez; John Nemunaitis; Andrea Kalinoski; Jian-Ting Zhang; Robert Damoiseaux; Paul Erhardt; F Charles Brunicardi
Journal:  Cancer Lett       Date:  2020-08-21       Impact factor: 8.679

Review 3.  Genetic factors affecting patient responses to pancreatic cancer treatment.

Authors:  George Fotopoulos; Konstantinos Syrigos; Muhammad Wasif Saif
Journal:  Ann Gastroenterol       Date:  2016-06-10

4.  Inhibition of Migration, Invasion and Drug Resistance of Pancreatic Adenocarcinoma Cells - Role of Snail, Slug and Twist and Small Molecule Inhibitors.

Authors:  Ezgi Kaşıkcı; Esra Aydemir; Ömer Faruk Bayrak; Fikrettin Şahin
Journal:  Onco Targets Ther       Date:  2020-06-18       Impact factor: 4.147

5.  The Effect of GPRC5a on the Proliferation, Migration Ability, Chemotherapy Resistance, and Phosphorylation of GSK-3β in Pancreatic Cancer.

Authors:  Bin Liu; Hai Yang; Christian Pilarsky; Georg F Weber
Journal:  Int J Mol Sci       Date:  2018-06-26       Impact factor: 5.923

6.  Enhancing effect of Panax ginseng on Zip4-mediated zinc influx into the cytosol.

Authors:  Yoshito Ikeda; Masayuki Munekane; Yasuyuki Yamada; Mizuki Kawakami; Ikuko Amano; Kohei Sano; Takahiro Mukai; Taiho Kambe; Nobukazu Shitan
Journal:  J Ginseng Res       Date:  2021-06-15       Impact factor: 5.735

7.  PAXgene Fixation for Pancreatic Cancer: Implications for Molecular and Surgical Pathology.

Authors:  Ryan DeCoste; Yutaka Amemiya; Sarah Nersesian; Lauren Westhaver; Stacey N Lee; Michael D Carter; Heidi L Sapp; Ashley E Stueck; Thomas Arnason; Jeanette Boudreau; Arun Seth; Weei-Yuarn Huang
Journal:  J Clin Med       Date:  2022-07-21       Impact factor: 4.964

8.  Inhibition of ZIP4 reverses epithelial-to-mesenchymal transition and enhances the radiosensitivity in human nasopharyngeal carcinoma cells.

Authors:  Qi Zeng; Yi-Min Liu; Jun Liu; Jian Han; Jian-Xin Guo; Shun Lu; Xue-Mei Huang; Ping Yi; Jin-Yi Lang; Peng Zhang; Chun-Ting Wang
Journal:  Cell Death Dis       Date:  2019-08-05       Impact factor: 8.469
  8 in total

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