Literature DB >> 25887776

Emerging EPO and EPO receptor regulators and signal transducers.

David Kuhrt1, Don M Wojchowski2.   

Abstract

As essential mediators of red cell production, erythropoietin (EPO) and its cell surface receptor (EPO receptor [EPOR]) have been intensely studied. Early investigations defined basic mechanisms for hypoxia-inducible factor induction of EPO expression, and within erythroid progenitors EPOR engagement of canonical Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5), rat sarcoma/mitogen-activated protein kinase/extracellular signal-regulated kinase (RAS/MEK/ERK), and phosphatidylinositol 3-kinase (PI3K) pathways. Contemporary genetic, bioinformatic, and proteomic approaches continue to uncover new clinically relevant modulators of EPO and EPOR expression, and EPO's biological effects. This Spotlight review highlights such factors and their emerging roles during erythropoiesis and anemia.
© 2015 by The American Society of Hematology.

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Year:  2015        PMID： 25887776      PMCID： PMC4458796          DOI： 10.1182/blood-2014-11-575357

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  93 in total

1.  Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo.

Authors:  Benjamin S Braun; Joehleen A Archard; Jessica A G Van Ziffle; David A Tuveson; Tyler E Jacks; Kevin Shannon
Journal:  Blood       Date:  2006-05-23       Impact factor: 22.113

Review 2.  Drugging the undruggable RAS: Mission possible?

Authors:  Adrienne D Cox; Stephen W Fesik; Alec C Kimmelman; Ji Luo; Channing J Der
Journal:  Nat Rev Drug Discov       Date:  2014-10-17       Impact factor: 84.694

3.  Genetic interaction between Kit and Scl.

Authors:  Julie Lacombe; Gorazd Krosl; Mathieu Tremblay; Bastien Gerby; Richard Martin; Peter D Aplan; Sebastien Lemieux; Trang Hoang
Journal:  Blood       Date:  2013-07-08       Impact factor: 22.113

4.  The anemic Friend virus gp55 envelope protein induces erythroid differentiation in fetal liver colony-forming units-erythroid.

Authors:  S N Constantinescu; H Wu; X Liu; W Beyer; A Fallon; H F Lodish
Journal:  Blood       Date:  1998-02-15       Impact factor: 22.113

5.  Expression cloning of the murine erythropoietin receptor.

Authors:  A D D'Andrea; H F Lodish; G G Wong
Journal:  Cell       Date:  1989-04-21       Impact factor: 41.582

6.  Cbl negatively regulates erythropoietin-induced growth and survival signaling through the proteasomal degradation of Src kinase.

Authors:  Takamichi Shintani; Fusako Ohara-Waki; Akira Kitanaka; Terukazu Tanaka; Yoshitsugu Kubota
Journal:  Blood Cells Mol Dis       Date:  2014-07-29       Impact factor: 3.039

7.  Erythropoietin-induced phosphorylation/degradation of BIM contributes to survival of erythroid cells.

Authors:  Randolph M Abutin; Jingchun Chen; Tina K Lung; Joyce A Lloyd; Stephen T Sawyer; Hisashi Harada
Journal:  Exp Hematol       Date:  2008-12-18       Impact factor: 3.084

Review 8.  Rho GTPases in erythroid maturation.

Authors:  Theodosia A Kalfa; Yi Zheng
Journal:  Curr Opin Hematol       Date:  2014-05       Impact factor: 3.284

9.  Selective reduction of JAK2V617F-dependent cell growth by siRNA/shRNA and its reversal by cytokines.

Authors:  Abire Jedidi; Caroline Marty; Charleen Oligo; Laurence Jeanson-Leh; Jean-Antoine Ribeil; Nicole Casadevall; Anne Galy; William Vainchenker; Jean-Luc Villeval
Journal:  Blood       Date:  2009-07-09       Impact factor: 22.113

Review 10.  Erythropoietin and the heart: physiological effects and the therapeutic perspective.

Authors:  Fabian Sanchis-Gomar; José Luis Garcia-Gimenez; Helios Pareja-Galeano; Marco Romagnoli; Carme Perez-Quilis; Giuseppe Lippi
Journal:  Int J Cardiol       Date:  2013-12-18       Impact factor: 4.164
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  58 in total

Review 1.  New strategies to target iron metabolism for the treatment of beta thalassemia.

Authors:  Paraskevi Rea Oikonomidou; Carla Casu; Stefano Rivella
Journal:  Ann N Y Acad Sci       Date:  2016-02-25       Impact factor: 5.691

2.  Identification and transcriptome analysis of erythroblastic island macrophages.

Authors:  Wei Li; Yaomei Wang; Huizhi Zhao; Huan Zhang; Yuanlin Xu; Shihui Wang; Xinhua Guo; Yumin Huang; Shijie Zhang; Yongshuai Han; Xianfang Wu; Charles M Rice; Gang Huang; Patrick G Gallagher; Avital Mendelson; Karina Yazdanbakhsh; Jing Liu; Lixiang Chen; Xiuli An
Journal:  Blood       Date:  2019-05-17       Impact factor: 22.113

3.  Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: a "U-shaped" relationship.

Authors:  Mingjun Shi; Brianna Flores; Peng Li; Nancy Gillings; Kathryn L McMillan; Jianfeng Ye; Lily Jun-Shen Huang; Sachdev S Sidhu; Yong-Ping Zhong; Maria T Grompe; Philip R Streeter; Orson W Moe; Ming Chang Hu
Journal:  Am J Physiol Renal Physiol       Date:  2017-11-29

4.  Phospho-PTM proteomic discovery of novel EPO- modulated kinases and phosphatases, including PTPN18 as a positive regulator of EPOR/JAK2 Signaling.

Authors:  Matthew A Held; Emily Greenfest-Allen; Su Su; Christian J Stoeckert; Matthew P Stokes; Don M Wojchowski
Journal:  Cell Signal       Date:  2020-02-03       Impact factor: 4.315

5.  Efficacy estimation of erythropoiesis-stimulating agents using erythropoietin-deficient anemic mice.

Authors:  Norio Suzuki; Yusuke Sasaki; Koichiro Kato; Shun Yamazaki; Mitsue Kurasawa; Keigo Yorozu; Yasushi Shimonaka; Masayuki Yamamoto
Journal:  Haematologica       Date:  2016-05-31       Impact factor: 9.941

6.  Efficacy and safety of ruxolitinib in regularly transfused patients with thalassemia: results from a phase 2a study.

Authors:  Ali T Taher; Zeynep Karakas; Elena Cassinerio; Noppadol Siritanaratkul; Antonis Kattamis; Aurelio Maggio; Stefano Rivella; Norbert Hollaender; Bruyère Mahuzier; Brian Gadbaw; Yesim Aydinok
Journal:  Blood       Date:  2017-11-02       Impact factor: 22.113

7.  Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.

Authors:  Ah Ram Kim; Jacob C Ulirsch; Stephan Wilmes; Ekrem Unal; Ignacio Moraga; Musa Karakukcu; Daniel Yuan; Shideh Kazerounian; Nour J Abdulhay; David S King; Namrata Gupta; Stacey B Gabriel; Eric S Lander; Turkan Patiroglu; Alper Ozcan; Mehmet Akif Ozdemir; K Christopher Garcia; Jacob Piehler; Hanna T Gazda; Daryl E Klein; Vijay G Sankaran
Journal:  Cell       Date:  2017-03-09       Impact factor: 41.582

8.  Acute blood loss stimulates fibroblast growth factor 23 production.

Authors:  Seham Rabadi; Ikemesit Udo; David E Leaf; Sushrut S Waikar; Marta Christov
Journal:  Am J Physiol Renal Physiol       Date:  2017-09-06

9.  DMOG, a Prolyl Hydroxylase Inhibitor, Increases Hemoglobin Levels without Exacerbating Hypertension and Renal Injury in Salt-Sensitive Hypertensive Rats.

Authors:  Sota Kato; Teisuke Takahashi; Noriyuki Miyata; Richard J Roman
Journal:  J Pharmacol Exp Ther       Date:  2019-12-04       Impact factor: 4.030

Review 10.  Targeting EPO and EPO receptor pathways in anemia and dysregulated erythropoiesis.

Authors:  Nicole Rainville; Edward Jachimowicz; Don M Wojchowski
Journal:  Expert Opin Ther Targets       Date:  2015-09-30       Impact factor: 6.902
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