Literature DB >> 25886128

Determination of florfenicol residues in broiler meat and liver samples using RP-HPLC with UV-visible detection.

Asma Nasim1, Bilal Aslam1, Ijaz Javed1, Asghar Ali1, Faqir Muhammad1, Ahmad Raza1, Zia-ud-Din Sindhu2.   

Abstract

BACKGROUND: Broilers are vulnerable to various types of microorganisms, including Salmonella, Escherichia coli and Staphylococcus aureus, resulting in multiple infections. Broad-spectrum antibacterial drugs such as florfenicol (FF) are widely used in the treatment of such infections. Suspected residues of these drugs in body tissues of treated birds can be passed to humans through meat consumption and thus lead to serious ill effects on human health. The present study was designed to estimate the presence of FF residues in broiler meat and liver samples.
RESULTS: The mean residual concentrations of FF in broiler meat and liver samples were 311.42 ± 186.56 and 2585.44 ± 1759.71 µg kg(-1) respectively, which are higher than their respective maximum residual limits (MRLs). The results showed that 126 and 24 samples were FF-positive and FF-negative respectively. Of the positive samples, 84 and 42 samples were above and below the MRL respectively.
CONCLUSION: The results indicate the presence of FF residues in broiler meat and liver samples. Usage of this contaminated meat causes resistance in consumers and poses a public health threat. Thus there is a need to educate farmers about the ill effects of residual drugs on human health and their withdrawal times in poultry.
© 2015 Society of Chemical Industry. © 2015 Society of Chemical Industry.

Entities:  

Keywords:  broilers; florfenicol residues; high-performance liquid chromatography; liver; meat

Mesh:

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Year:  2015        PMID: 25886128     DOI: 10.1002/jsfa.7220

Source DB:  PubMed          Journal:  J Sci Food Agric        ISSN: 0022-5142            Impact factor:   3.638


  3 in total

1.  Florfenicol Enhances Colonization of a Salmonella enterica Serovar Enteritidis floR Mutant with Major Alterations to the Intestinal Microbiota and Metabolome in Neonatal Chickens.

Authors:  Xueran Mei; Boheng Ma; Xiwen Zhai; Anyun Zhang; Changwei Lei; Lei Zuo; Xin Yang; Changyu Zhou; Hongning Wang
Journal:  Appl Environ Microbiol       Date:  2021-10-06       Impact factor: 5.005

2.  Development and Validation of a Stability-Indicating HPLC Method for the Simultaneous Determination of Florfenicol and Flunixin Meglumine Combination in an Injectable Solution.

Authors:  Nidal Batrawi; Hani Naseef; Fuad Al-Rimawi
Journal:  J Anal Methods Chem       Date:  2017-07-11       Impact factor: 2.193

3.  Proteome and transcriptome analysis revealed florfenicol via affected drug metabolism and lipid metabolism induce liver injury of broilers.

Authors:  Chao Han; Yuqing Cui; Yiwei Guo; Di Zhang; Xiao Wang; Yumeng Geng; Wanyu Shi; Yongzhan Bao
Journal:  Poult Sci       Date:  2021-05-04       Impact factor: 3.352

  3 in total

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