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Literature DB >> 25886070

Giant mice reveal new roles for GH in regulating the adipose immune microenvironment.

Angela K Odle¹, Paul D Drew, Gwen V Childs.

Abstract

Entities: Species

Mesh：

Substances：
Growth Hormone

Year: 2015 PMID： 25886070 PMCID： PMC4398772 DOI： 10.1210/en.2015-1205

Source DB: PubMed Journal: Endocrinology ISSN： 0013-7227 Impact factor: 4.736

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References

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6. Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity.

Authors: S R Smith; J C Lovejoy; F Greenway; D Ryan; L deJonge; J de la Bretonne; J Volafova; G A Bray
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Giant mice reveal new roles for GH in regulating the adipose immune microenvironment.

1. A Contribution to the Study of the Morphology of Adipose Tissue.

2. Adipokine protein expression pattern in growth hormone deficiency predisposes to the increased fat cell size and the whole body metabolic derangements.

3. Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I.

4. The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity.

5. Effects of leptin replacement on hypothalamic-pituitary growth hormone axis function and circulating ghrelin levels in ob/ob mice.

6. Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity.

Review 7. Expression, regulation and biological actions of growth hormone (GH) and ghrelin in the immune system.

8. The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity.

9. The lung innate immune gene surfactant protein-D is expressed in adipose tissue and linked to obesity status.

Review 10. Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects.