Literature DB >> 25885277

Motor neuron transduction after intracisternal delivery of AAV9 in a cynomolgus macaque.

Peter Bell1, Christian Hinderer, Jean-Pierre Louboutin, Hongwei Yu, Rebecca Grant, Erin Bote, James M Wilson.   

Abstract

The image shows a section of the lumbar spinal cord from a cynomolgus macaque that had received AAV9.CB.EGFP via the cisterna magna. Expression of GFP in multiple motor neurons is visible. Injection into the cerebrospinal fluid has been shown to be an effective route of vector administration for neuron transduction.

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Year:  2015        PMID: 25885277     DOI: 10.1089/hgtb.2015.041

Source DB:  PubMed          Journal:  Hum Gene Ther Methods        ISSN: 1946-6536            Impact factor:   2.396


  2 in total

1.  Subpial Adeno-associated Virus 9 (AAV9) Vector Delivery in Adult Mice.

Authors:  Takahiro Tadokoro; Atsushi Miyanohara; Michael Navarro; Kota Kamizato; Stefan Juhas; Jana Juhasova; Silvia Marsala; Oleksandr Platoshyn; Erik Curtis; Brandon Gabel; Joseph Ciacci; Nada Lukacova; Katarina Bimbova; Martin Marsala
Journal:  J Vis Exp       Date:  2017-07-13       Impact factor: 1.355

2.  Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs.

Authors:  Atsushi Miyanohara; Kota Kamizato; Stefan Juhas; Jana Juhasova; Michael Navarro; Silvia Marsala; Nada Lukacova; Marian Hruska-Plochan; Erik Curtis; Brandon Gabel; Joseph Ciacci; Eric T Ahrens; Brian K Kaspar; Don Cleveland; Martin Marsala
Journal:  Mol Ther Methods Clin Dev       Date:  2016-07-13       Impact factor: 6.698

  2 in total

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