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Literature DB >> 25882463

Multifaceted contributions of epidermal langerhans cells to cutaneous carcinogenesis.

Abstract

Recent findings have established that epidermal Langerhans cells (LCs) promote polyaromatic hydrocarbon (PAH)-induced carcinogenesis independent of their immunological properties by generating mutagenic PAH metabolites. In this issue, Girardi and colleagues (2014) extend their previous work and demonstrate that this mutagenic metabolism of LCs is indeed mediated by preferential expression of the cytochrome P450 enzyme CYP1B1, but that LCs cells exert their pro-carcinogenic effects also independently of CYP1B1.

Entities: Chemical Disease Gene

Mesh：

Substances：
Mutagens

Year: 2015 PMID： 25882463 DOI： 10.1038/jid.2014.520

Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551

18 in total

1. Ultraviolet-B exposure of human skin induces cytochromes P450 1A1 and 1B1.

Authors: S K Katiyar; M S Matsui; H Mukhtar
Journal: J Invest Dermatol Date: 2000-02 Impact factor: 8.551

2. IL-18 reduces ultraviolet radiation-induced DNA damage and thereby affects photoimmunosuppression.

Authors: Agatha Schwarz; Akira Maeda; Sonja Ständer; Harry van Steeg; Thomas Schwarz
Journal: J Immunol Date: 2006-03-01 Impact factor: 5.422

Review 3. The aryl hydrocarbon receptor: multitasking in the immune system.

Authors: Brigitta Stockinger; Paola Di Meglio; Manolis Gialitakis; João H Duarte
Journal: Annu Rev Immunol Date: 2014 Impact factor: 28.527

4. Langerhans cells facilitate epithelial DNA damage and squamous cell carcinoma.

Authors: Badri G Modi; Jason Neustadter; Elisa Binda; Julia Lewis; Renata B Filler; Scott J Roberts; Bernice Y Kwong; Swapna Reddy; John D Overton; Anjela Galan; Robert Tigelaar; Lining Cai; Peter Fu; Mark Shlomchik; Daniel H Kaplan; Adrian Hayday; Michael Girardi
Journal: Science Date: 2012-01-06 Impact factor: 47.728

5. mRNA expression of multiple cytochrome p450 isozymes in four types of cultured skin cells.

Authors: Mayumi Saeki; Yoshiro Saito; Michiyo Nagano; Reiko Teshima; Shogo Ozawa; Jun-ichi Sawada
Journal: Int Arch Allergy Immunol Date: 2002-04 Impact factor: 2.749

6. Langerhans cell maturation and contact hypersensitivity are impaired in aryl hydrocarbon receptor-null mice.

Authors: Bettina Jux; Stephanie Kadow; Charlotte Esser
Journal: J Immunol Date: 2009-06-01 Impact factor: 5.422

7. Langerhans cells are required for UVR-induced immunosuppression.

Authors: Agatha Schwarz; Madelon Noordegraaf; Akira Maeda; Kan Torii; Björn E Clausen; Thomas Schwarz
Journal: J Invest Dermatol Date: 2010-01-21 Impact factor: 8.551

8. Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation.

Authors: Ellen Fritsche; Claudia Schäfer; Christian Calles; Thorsten Bernsmann; Thorsten Bernshausen; Melanie Wurm; Ulrike Hübenthal; Jason E Cline; Hossein Hajimiragha; Peter Schroeder; Lars-Oliver Klotz; Agneta Rannug; Peter Fürst; Helmut Hanenberg; Josef Abel; Jean Krutmann
Journal: Proc Natl Acad Sci U S A Date: 2007-05-14 Impact factor: 11.205

Multifaceted contributions of epidermal langerhans cells to cutaneous carcinogenesis.

1. Ultraviolet-B exposure of human skin induces cytochromes P450 1A1 and 1B1.

2. IL-18 reduces ultraviolet radiation-induced DNA damage and thereby affects photoimmunosuppression.

Review 3. The aryl hydrocarbon receptor: multitasking in the immune system.

4. Langerhans cells facilitate epithelial DNA damage and squamous cell carcinoma.

5. mRNA expression of multiple cytochrome p450 isozymes in four types of cultured skin cells.

6. Langerhans cell maturation and contact hypersensitivity are impaired in aryl hydrocarbon receptor-null mice.

7. Langerhans cells are required for UVR-induced immunosuppression.

8. Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation.

9. Aryl hydrocarbon receptor plays a significant role in mediating airborne particulate-induced carcinogenesis in mice.

10. Mechanisms of chemical cooperative carcinogenesis by epidermal Langerhans cells.

1. Pak1 maintains epidermal stem cells by regulating Langerhans cells and is required for skin carcinogenesis.

Review 2. Functional Specialization of Skin Dendritic Cell Subsets in Regulating T Cell Responses.