Literature DB >> 25882365

First report of linezolid dependence in methicillin-resistant Staphylococcus aureus.

I López-Hernández1, M Delgado Valverde2, N Batista Díaz2, A Pascual3.   

Abstract

Linezolid is used to treat infections caused by methicillin-resistant Staphylococcus aureus (MRSA). We describe the first report of linezolid dependence in MRSA. The strain was isolated from a respiratory sample of a cystic fibrosis patient, and it showed a thymidine-dependent small-colony variant phenotype. The effect was not related to any known mechanisms implicated in S. aureus resistance to linezolid. The clinical significance of this phenomenon needs further investigation.
Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

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Keywords:  Cystic fibrosis; MRSA; dependence; linezolid; small-colony variant

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Year:  2015        PMID： 25882365     DOI： 10.1016/j.cmi.2015.03.012

Source DB:  PubMed          Journal:  Clin Microbiol Infect        ISSN： 1198-743X            Impact factor:   8.067


  1 in total

1.  In-Host Emergence of Linezolid Resistance in a Complex Pattern of Toxic Shock Syndrome Toxin-1-Positive Methicillin-Resistant Staphylococcus aureus Colonization in Siblings with Cystic Fibrosis.

Authors:  Agathe Boudet; Alexandre Jay; Catherine Dunyach-Remy; Raphaël Chiron; Jean-Philippe Lavigne; Hélène Marchandin
Journal:  Toxins (Basel)       Date:  2021-04-28       Impact factor: 4.546
  1 in total

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