Dimah Saade1, Charuta Joshi2. 1. Division of Pediatric Neurology, University of Iowa Children's Hospital, Iowa City, Iowa. Electronic address: dimah-saade@uiowa.edu. 2. Division of Pediatric Neurology, University of Iowa Children's Hospital, Iowa City, Iowa.
Abstract
BACKGROUND: Malignant migrating partial seizures in infancy is a devastating pharmacoresistent epileptic encephalopathy of unknown etiology characterized by onset in the first 6 months of life, continuous migrating focal seizures with corresponding multifocal electroencephalographic discharges, developmental deterioration, and early mortality. Recent widespread interest in the nonpsychoactive component of the cannabis plant, cannabidiol, as a potential treatment for refractory devastating epilepsies has led to individual trials initiated by families or physicians in states that have legalized medical marijuana with anecdotal success. PATIENT DESCRIPTION: We describe a now 10-month-old boy with malignant migrating partial seizures in infancy who made developmental gains and demonstrated sustained seizure reduction with the addition of cannabidiol to his antiepileptic regimen. CONCLUSION: This report supports a role for cannabidiol in the treatment of malignant migrating partial seizures in infancy.
BACKGROUND: Malignant migrating partial seizures in infancy is a devastating pharmacoresistent epilepticencephalopathy of unknown etiology characterized by onset in the first 6 months of life, continuous migrating focal seizures with corresponding multifocal electroencephalographic discharges, developmental deterioration, and early mortality. Recent widespread interest in the nonpsychoactive component of the cannabis plant, cannabidiol, as a potential treatment for refractory devastating epilepsies has led to individual trials initiated by families or physicians in states that have legalized medical marijuana with anecdotal success. PATIENT DESCRIPTION: We describe a now 10-month-old boy with malignant migrating partial seizures in infancy who made developmental gains and demonstrated sustained seizure reduction with the addition of cannabidiol to his antiepileptic regimen. CONCLUSION: This report supports a role for cannabidiol in the treatment of malignant migrating partial seizures in infancy.