Literature DB >> 25881971

Heteroatom-substituted tetra(3,4-pyrido)porphyrazines: a stride toward near-infrared-absorbing macrocycles.

Lenka Vachova1, Miloslav Machacek, Radim Kučera, Jiri Demuth, Pavel Cermak, Kamil Kopecky, Miroslav Miletin, Adela Jedlickova, Tomas Simunek, Veronika Novakova, Petr Zimcik.   

Abstract

A synthesis procedure for heteroatom-substituted tetra(3,4-pyrido)porphyrazines that absorb light near 800 nm was developed. Based on the observed relationships between the structure and photophysical parameters, a novel highly photodynamically active (IC50 = 0.26 μM) compound was synthesized and biologically characterized.

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Year:  2015        PMID: 25881971     DOI: 10.1039/c5ob00651a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN: 1477-0520            Impact factor:   3.876


  1 in total

1.  Discovery of the Antitumor Effects of a Porphyrazine Diol (Pz 285) in MDA-MB-231 Breast Tumor Xenograft Models in Mice.

Authors:  Irawati K Kandela; Katherine J McAuliffe; Lauren E Cochran; Anthony G M Barrett; Brian M Hoffman; Andrew P Mazar; Evan R Trivedi
Journal:  ACS Med Chem Lett       Date:  2017-06-29       Impact factor: 4.345

  1 in total

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