Literature DB >> 25881954

Runx2: Structure, function, and phosphorylation in osteoblast differentiation.

S Vimalraj1, B Arumugam1, P J Miranda1, N Selvamurugan2.   

Abstract

Runx2 is a master transcription factor for osteogenesis. The most important phenomenon that makes this protein a master regulator for osteogenesis is its structural integrity. In response to various stimuli, the domains in Runx2 interact with several proteins and regulate a number of cellular events via posttranslational modifications. Hence, in this review we summarized the structural integrity of Runx2 and its posttranslational modifications, especially the phosphorylation responsible for either stimulation or inhibition of its regulatory role in osteogenesis.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Bone; Osteoblast; Phosphorylation; Runx2

Mesh：

Substances：

Year:  2015        PMID： 25881954     DOI： 10.1016/j.ijbiomac.2015.04.008

Source DB:  PubMed          Journal:  Int J Biol Macromol        ISSN： 0141-8130            Impact factor:   6.953


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