| Literature DB >> 25881907 |
Paola Piscopo1, Giuseppe Tosto2, Chiara Belli1, Giuseppina Talarico2, Daniela Galimberti3, Marina Gasparini2, Marco Canevelli2, Anna Poleggi1, Alessio Crestini1, Diego Albani4, Gianluigi Forloni4, Ugo Lucca4, Pierluigi Quadri5, Mauro Tettamanti4, Chiara Fenoglio3, Elio Scarpini3, Giuseppe Bruno2, Nicola Vanacore6, Annamaria Confaloni1.
Abstract
Several studies have established the sortilin-related receptor gene (SORL1) as a susceptibility locus for Alzheimer's disease (AD). Single nucleotide polymorphisms of SORL1 reported in literature as being associated with AD were investigated in an Italian case-control data set, and their role as a risk factor of conversion to AD was studied in an independent sample of subjects diagnosed with mild cognitive impairment (MCI) at baseline. rs641120, rs2070045, and rs1010159 were genotyped in 734 subjects diagnosed with AD (n = 338) and MCI (n = 181) and in healthy controls (n = 215). Our results confirmed the association between rs641120 and AD (p = 0.01). In the MCI cohort, rs1010159 was associated with conversion to AD (HR = 1.56, p = 0.002). Taken together, these findings confirm that SORL1 is associated with AD and might be a potential tool for identifying MCI subjects at high risk of conversion to AD.Entities:
Keywords: Alzheimer’s disease; SORL1; mild cognitive impairment; single nucleotide polymorphisms
Mesh：
Substances：
Year: 2015 PMID： 25881907 DOI： 10.3233/JAD-141551
Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472