Micah J Hill1, Greene Donald Royster2, Mae Wu Healy2, Kevin S Richter3, Gary Levy2, Alan H DeCherney4, Eric D Levens3, Geeta Suthar3, Eric Widra3, Michael J Levy3. 1. Shady Grove Fertility Reproductive Science Center, Rockville, Maryland; Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland. Electronic address: hillmicah@mail.nih.gov. 2. Shady Grove Fertility Reproductive Science Center, Rockville, Maryland; Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland. 3. Shady Grove Fertility Reproductive Science Center, Rockville, Maryland. 4. Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Abstract
OBJECTIVE: To evaluate if an elevated progesterone (P) level on the day of human chorionic gonadotropin (hCG) administration is associated with a decrease in live-birth rate in patients with a good prognosis. DESIGN: Retrospective cohort study. SETTING: Large, private, assisted reproductive technology (ART) practice. PATIENT(S): One thousand six hundred twenty fresh autologous ART cycles. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Live-birth rate. RESULT(S): A total of 934 blastocyst and 686 cleavage-stage embryo transfer (ET) cycles were evaluated. Serum P levels were not associated with markers of oocyte or embryo quality, including fertilization, embryo stage at transfer, and embryos available for cryopreservation. Patient age, stage of ET, embryo quality, the number of embryos transferred, and P level on the day of hCG administration were all significantly associated with live birth. Higher P levels were associated with decreased odds of live birth for cleavage- and blastocyst-stage embryos, poor-fair and good-quality embryos, and poor- and high-responder patients. The nonsignificance of interaction tests of P levels with embryo stage, embryo quality, patient age, and ovarian response indicated that the relationship between P level and live birth was similar regardless of these factors. CONCLUSION(S): An elevated serum P level on the day of hCG administration was negatively associated with live birth, even in ETs with a good prognosis. Published by Elsevier Inc.
OBJECTIVE: To evaluate if an elevated progesterone (P) level on the day of human chorionic gonadotropin (hCG) administration is associated with a decrease in live-birth rate in patients with a good prognosis. DESIGN: Retrospective cohort study. SETTING: Large, private, assisted reproductive technology (ART) practice. PATIENT(S): One thousand six hundred twenty fresh autologous ART cycles. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Live-birth rate. RESULT(S): A total of 934 blastocyst and 686 cleavage-stage embryo transfer (ET) cycles were evaluated. Serum P levels were not associated with markers of oocyte or embryo quality, including fertilization, embryo stage at transfer, and embryos available for cryopreservation. Patient age, stage of ET, embryo quality, the number of embryos transferred, and P level on the day of hCG administration were all significantly associated with live birth. Higher P levels were associated with decreased odds of live birth for cleavage- and blastocyst-stage embryos, poor-fair and good-quality embryos, and poor- and high-responder patients. The nonsignificance of interaction tests of P levels with embryo stage, embryo quality, patient age, and ovarian response indicated that the relationship between P level and live birth was similar regardless of these factors. CONCLUSION(S): An elevated serum P level on the day of hCG administration was negatively associated with live birth, even in ETs with a good prognosis. Published by Elsevier Inc.
Authors: Micah J Hill; Mae Wu Healy; Kevin S Richter; Eric Widra; Eric D Levens; Alan H DeCherney; George Patounakis; Brian W Whitcomb Journal: Fertil Steril Date: 2017-01-06 Impact factor: 7.329
Authors: Mae Wu Healy; Meghan Yamasaki; George Patounakis; Kevin S Richter; Kate Devine; Alan H DeCherney; Micah J Hill Journal: Hum Reprod Date: 2016-12-16 Impact factor: 6.918
Authors: Micah J Hill; G Donald Royster; Mansi Taneja; Mae Wu Healy; Shvetha M Zarek; Alicia Y Christy; Alan H DeCherney; Eric Widra; Kate Devine Journal: Reprod Biomed Online Date: 2016-11-16 Impact factor: 3.828
Authors: Greene Donald Royster; Kavitha Krishnamoorthy; John M Csokmay; Belinda J Yauger; Rebecca J Chason; Alan H DeCherney; Erin F Wolff; Micah J Hill Journal: Fertil Steril Date: 2016-05-10 Impact factor: 7.329
Authors: P Merviel; S Bouée; A S Jacamon; J J Chabaud; M T Le Martelot; S Roche; C Rince; H Drapier; A Perrin; D Beauvillard Journal: BMC Pregnancy Childbirth Date: 2021-05-06 Impact factor: 3.007