Sittisak Honsawek1, Vajara Wilairatana2, Wanvisa Udomsinprasert3, Peerasit Sinlapavilawan2, Napaphat Jirathanathornnukul3. 1. Department of Biochemistry and Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873, Rama IV road, Patumwan, 10330 Bangkok, Thailand; Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 10330 Bangkok, Thailand. Electronic address: Sittisak.H@chula.ac.th. 2. Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 10330 Bangkok, Thailand. 3. Department of Biochemistry and Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873, Rama IV road, Patumwan, 10330 Bangkok, Thailand.
Abstract
OBJECTIVE: To investigate plasma and synovial fluid (SF) periostin of knee osteoarthritis (OA) patients and to determine the relationship between periostin levels and the radiographic severity. METHODS: A total of 110 subjects (90 knee OA patients and 20 healthy controls) were enrolled in this study. Plasma and SF periostin were examined using an enzyme-linked immunosorbent assay. OA grading was performed using the Kellgren-Lawrence classification. RESULTS: Although plasma periostin was greater in OA patients than in controls, the difference was not significant. Additionally, SF periostin was significantly higher with respect to paired plasma (P<0.001). Moreover, plasma and SF periostin demonstrated significantly positive correlation with the radiographic severity of knee OA (r=0.537, P<0.001 and r=0.427, P<0.001, respectively). Subsequent analysis revealed that there was a positive correlation between plasma and SF periostin (r=0.368, P<0.001). CONCLUSIONS: Plasma and SF periostin levels were positively correlated with the radiographic severity of knee OA.
OBJECTIVE: To investigate plasma and synovial fluid (SF) periostin of knee osteoarthritis (OA) patients and to determine the relationship between periostin levels and the radiographic severity. METHODS: A total of 110 subjects (90 knee OA patients and 20 healthy controls) were enrolled in this study. Plasma and SF periostin were examined using an enzyme-linked immunosorbent assay. OA grading was performed using the Kellgren-Lawrence classification. RESULTS: Although plasma periostin was greater in OA patients than in controls, the difference was not significant. Additionally, SF periostin was significantly higher with respect to paired plasma (P<0.001). Moreover, plasma and SF periostin demonstrated significantly positive correlation with the radiographic severity of knee OA (r=0.537, P<0.001 and r=0.427, P<0.001, respectively). Subsequent analysis revealed that there was a positive correlation between plasma and SF periostin (r=0.368, P<0.001). CONCLUSIONS: Plasma and SF periostin levels were positively correlated with the radiographic severity of knee OA.
Authors: R H Brophy; L Cai; X Duan; Q Zhang; R R Townsend; R M Nunley; F Guilak; M F Rai Journal: Osteoarthritis Cartilage Date: 2019-08-17 Impact factor: 6.576
Authors: N Chinzei; R H Brophy; X Duan; L Cai; R M Nunley; L J Sandell; M F Rai Journal: Osteoarthritis Cartilage Date: 2018-01-31 Impact factor: 6.576
Authors: Xin Duan; Lei Cai; Christine T N Pham; Yousef Abu-Amer; Hua Pan; Robert H Brophy; Samuel A Wickline; Muhammad Farooq Rai Journal: Arthritis Rheumatol Date: 2021-10-28 Impact factor: 15.483
Authors: Mukundan Attur; Xin Duan; Lei Cai; Tianzhen Han; Weili Zhang; Eric D Tycksen; Jonathan Samuels; Robert H Brophy; Steven B Abramson; Muhammad Farooq Rai Journal: Arthritis Res Ther Date: 2021-04-08 Impact factor: 5.156
Authors: Zhong Li; Zixuan Lin; Silvia Liu; Haruyo Yagi; Xiurui Zhang; Lauren Yocum; Monica Romero-Lopez; Claire Rhee; Meagan J Makarcyzk; Ilhan Yu; Eileen N Li; Madalyn R Fritch; Qi Gao; Kek Boon Goh; Benjamen O'Donnell; Tingjun Hao; Peter G Alexander; Bhushan Mahadik; John P Fisher; Stuart B Goodman; Bruce A Bunnell; Rocky S Tuan; Hang Lin Journal: Adv Sci (Weinh) Date: 2022-04-18 Impact factor: 17.521