Literature DB >> 25881554

PARP-1 involvement in neurodegeneration: A focus on Alzheimer's and Parkinson's diseases.

Sara Martire1, Luciana Mosca1, Maria d'Erme2.   

Abstract

DNA damage is the prime activator of the enzyme poly(ADP-ribose)polymerase1 (PARP-1) whose overactivation has been proven to be associated with the pathogenesis of numerous central nervous system disorders, such as ischemia, neuroinflammation, and neurodegenerative diseases. Under oxidative stress conditions PARP-1 activity increases, leading to an accumulation of ADP-ribose polymers and NAD(+) depletion, that induces energy crisis and finally cell death. This review aims to explain the contribution of PARP-1 in neurodegenerative diseases, focusing on Alzheimer's and Parkinson's disease, to stimulate further studies on this issue and thereby engage a new perspective regarding the design of possible therapeutic agents or the identification of biomarkers.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Alzheimer’s disease; Mitochondria; Parkinson’s disease; Poly(ADP-ribose)polymerase

Mesh：

Substances：

Year:  2015        PMID： 25881554     DOI： 10.1016/j.mad.2015.04.001

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN： 0047-6374            Impact factor:   5.432


  73 in total

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Authors:  Sean W Reilly; Laura N Puentes; Alexander Schmitz; Chia-Ju Hsieh; Chi-Chang Weng; Catherine Hou; Shihong Li; Yin-Ming Kuo; Prashanth Padakanti; Hsiaoju Lee; Aladdin A Riad; Mehran Makvandi; Robert H Mach
Journal:  Bioorg Chem       Date:  2018-10-17       Impact factor: 5.275

2.  Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3-dependent mechanism in male mice.

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3.  Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity.

Authors:  Sean W Reilly; Laura N Puentes; Khadija Wilson; Chia-Ju Hsieh; Chi-Chang Weng; Mehran Makvandi; Robert H Mach
Journal:  J Med Chem       Date:  2018-06-14       Impact factor: 7.446

Review 4.  Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.

Authors:  Jesse S Kerr; Bryan A Adriaanse; Nigel H Greig; Mark P Mattson; M Zameel Cader; Vilhelm A Bohr; Evandro F Fang
Journal:  Trends Neurosci       Date:  2017-02-09       Impact factor: 13.837

Review 5.  PARP-1 and its associated nucleases in DNA damage response.

Authors:  Yijie Wang; Weibo Luo; Yingfei Wang
Journal:  DNA Repair (Amst)       Date:  2019-07-08

6.  PARP1 inhibition alleviates injury in ARH3-deficient mice and human cells.

Authors:  Masato Mashimo; Xiangning Bu; Kazumasa Aoyama; Jiro Kato; Hiroko Ishiwata-Endo; Linda A Stevens; Atsushi Kasamatsu; Lynne A Wolfe; Camilo Toro; David Adams; Thomas Markello; William A Gahl; Joel Moss
Journal:  JCI Insight       Date:  2019-02-21

Review 7.  The PARP family: insights into functional aspects of poly (ADP-ribose) polymerase-1 in cell growth and survival.

Authors:  T Jubin; A Kadam; M Jariwala; S Bhatt; S Sutariya; A R Gani; S Gautam; R Begum
Journal:  Cell Prolif       Date:  2016-06-22       Impact factor: 6.831

8.  NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.

Authors:  Yujun Hou; Sofie Lautrup; Stephanie Cordonnier; Yue Wang; Deborah L Croteau; Eduardo Zavala; Yongqing Zhang; Kanako Moritoh; Jennifer F O'Connell; Beverly A Baptiste; Tinna V Stevnsner; Mark P Mattson; Vilhelm A Bohr
Journal:  Proc Natl Acad Sci U S A       Date:  2018-02-05       Impact factor: 11.205

9.  A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1.

Authors:  Yingfei Wang; Ran An; George K Umanah; Hyejin Park; Kalyani Nambiar; Stephen M Eacker; BongWoo Kim; Lei Bao; Maged M Harraz; Calvin Chang; Rong Chen; Jennifer E Wang; Tae-In Kam; Jun Seop Jeong; Zhi Xie; Stewart Neifert; Jiang Qian; Shaida A Andrabi; Seth Blackshaw; Heng Zhu; Hongjun Song; Guo-Li Ming; Valina L Dawson; Ted M Dawson
Journal:  Science       Date:  2016-10-07       Impact factor: 47.728

10.  The role of poly(ADP-ribose) polymerases in manganese exposed Caenorhabditis elegans.

Authors:  Catherine Neumann; Jessica Baesler; Gereon Steffen; Merle Marie Nicolai; Tabea Zubel; Michael Aschner; Alexander Bürkle; Aswin Mangerich; Tanja Schwerdtle; Julia Bornhorst
Journal:  J Trace Elem Med Biol       Date:  2019-09-14       Impact factor: 3.849
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