INTRODUCTION: Dengue is endemic in the tropics, and complications involving organ systems are seen with varying incidence. METHODOLOGY: We performed a systematic review. MEDLINE, EMBASE, Scopus SciVerse, Google Scholar, and LILACS were searched for papers providing information on cardiac involvement in dengue. RESULTS: Cardiac involvement is not uncommon in dengue infection and is often transient, but may be associated with significant morbidity and even mortality. Direct viral invasion, immune mechanisms, electrolyte imbalance, derangement of intracellular calcium ion storage, lactic acidosis, and ischemia due to hypotension all play a role in myocardial dysfunction. The manifestations of cardiac involvement include clinical, electrocardiographic, echocardiographic, cardiac enzyme, and histopathologic abnormalities. Echocardiography appears to be a useful tool for detecting myocardial involvement and should be performed in patients with electrocardiographic abnormalities or hemodynamic instability. Treatment is largely supportive, though there are some anecdotal reports of improvements with specific agents. CONCLUSIONS: Knowledge on cardiac manifestations in dengue is limited, and further studies are needed to establish the exact pathophysiology and role of specific agents in the prevention and treatment of cardiac complications in dengue.
INTRODUCTION: Dengue is endemic in the tropics, and complications involving organ systems are seen with varying incidence. METHODOLOGY: We performed a systematic review. MEDLINE, EMBASE, Scopus SciVerse, Google Scholar, and LILACS were searched for papers providing information on cardiac involvement in dengue. RESULTS:Cardiac involvement is not uncommon in dengue infection and is often transient, but may be associated with significant morbidity and even mortality. Direct viral invasion, immune mechanisms, electrolyte imbalance, derangement of intracellular calcium ion storage, lactic acidosis, and ischemia due to hypotension all play a role in myocardial dysfunction. The manifestations of cardiac involvement include clinical, electrocardiographic, echocardiographic, cardiac enzyme, and histopathologic abnormalities. Echocardiography appears to be a useful tool for detecting myocardial involvement and should be performed in patients with electrocardiographic abnormalities or hemodynamic instability. Treatment is largely supportive, though there are some anecdotal reports of improvements with specific agents. CONCLUSIONS: Knowledge on cardiac manifestations in dengue is limited, and further studies are needed to establish the exact pathophysiology and role of specific agents in the prevention and treatment of cardiac complications in dengue.
Authors: Diego Araiza-Garaygordobil; Carlos Eduardo García-Martínez; Lucrecia María Burgos; Clara Saldarriaga; Kiera Liblik; Ivan Mendoza; Manuel Martinez-Selles; Cristhian Emmanuel Scatularo; Juan Maria Farina; Adrian Baranchuk Journal: Cardiovasc J Afr Date: 2021-07-20 Impact factor: 1.167
Authors: Arthur da Costa Rasinhas; Fernanda Cunha Jácome; Gabriela Cardoso Caldas; Ana Luisa Teixeira de Almeida; Marcos Alexandre Nunes da Silva; Daniel Dias Coutinho de Souza; Amanda Carlos Paulino; Derick Mendes Bandeira; Raphael Leonardo; Priscila Conrado Guerra Nunes; Ronaldo Mohana-Borges; Ortrud Monika Barth; Flavia Barreto Dos Santos; Debora Ferreira Barreto Vieira Journal: Viruses Date: 2021-09-29 Impact factor: 5.048