BACKGROUND: Genetic and non-genetic factors probably act together to initiate and accelerate development of type 1 diabetes [T1D]. One suggested risk factor contributing to development of T1D is air pollution. OBJECTIVE: The aim of the study was to investigate whether maternal exposure during pregnancy to air pollution, measured as nitrogen oxides [NOx] and ozone, in a low-dose exposure area was associated with the child developing T1D. METHOD: In Scania (Skåne), the most southern county in Sweden, 84,039 infants were born during the period 1999-2005. By the end of April 2013, 324 of those children had been diagnosed with T1D. For each of those T1D children three control children were randomly selected and matched for HLA genotype and birth year. Individually modelled exposure data at residence during pregnancy were assessed for nitrogen oxides [NOx], traffic density and ozone. RESULTS: Ozone as well as NOx exposures were associated with T1D. When the highest exposure group was compared to the lowest group an odds ratios of 1.62 (95% confidence interval [CI] 0.99-2.65) was observed for ozone in the second trimester and 1.58 (95% CI 1.06-2.35) for NOx in the third trimester. CONCLUSION: This study indicates that living in an area with elevated levels of air pollution during pregnancy may be a risk factor for offspring T1D.
BACKGROUND: Genetic and non-genetic factors probably act together to initiate and accelerate development of type 1 diabetes [T1D]. One suggested risk factor contributing to development of T1D is air pollution. OBJECTIVE: The aim of the study was to investigate whether maternal exposure during pregnancy to air pollution, measured as nitrogen oxides [NOx] and ozone, in a low-dose exposure area was associated with the child developing T1D. METHOD: In Scania (Skåne), the most southern county in Sweden, 84,039 infants were born during the period 1999-2005. By the end of April 2013, 324 of those children had been diagnosed with T1D. For each of those T1D children three control children were randomly selected and matched for HLA genotype and birth year. Individually modelled exposure data at residence during pregnancy were assessed for nitrogen oxides [NOx], traffic density and ozone. RESULTS: Ozone as well as NOx exposures were associated with T1D. When the highest exposure group was compared to the lowest group an odds ratios of 1.62 (95% confidence interval [CI] 0.99-2.65) was observed for ozone in the second trimester and 1.58 (95% CI 1.06-2.35) for NOx in the third trimester. CONCLUSION: This study indicates that living in an area with elevated levels of air pollution during pregnancy may be a risk factor for offspring T1D.
Authors: George D Thurston; Howard Kipen; Isabella Annesi-Maesano; John Balmes; Robert D Brook; Kevin Cromar; Sara De Matteis; Francesco Forastiere; Bertil Forsberg; Mark W Frampton; Jonathan Grigg; Dick Heederik; Frank J Kelly; Nino Kuenzli; Robert Laumbach; Annette Peters; Sanjay T Rajagopalan; David Rich; Beate Ritz; Jonathan M Samet; Thomas Sandstrom; Torben Sigsgaard; Jordi Sunyer; Bert Brunekreef Journal: Eur Respir J Date: 2017-01-11 Impact factor: 16.671
Authors: Chelsea A O'Driscoll; Leah A Owens; Erica J Hoffmann; Madeline E Gallo; Amin Afrazi; Mei Han; John H Fechner; James J Schauer; Christopher A Bradfield; Joshua D Mezrich Journal: Environ Res Date: 2018-10-01 Impact factor: 6.498
Authors: Desinia B Miller; Samantha J Snow; Andres Henriquez; Mette C Schladweiler; Allen D Ledbetter; Judy E Richards; Debora L Andrews; Urmila P Kodavanti Journal: Toxicol Appl Pharmacol Date: 2016-06-28 Impact factor: 4.219
Authors: Wei Liu; Minjia Zhang; Jinqiu Feng; Aiqin Fan; Yalin Zhou; Yajun Xu Journal: Int J Environ Res Public Health Date: 2017-06-02 Impact factor: 3.390
Authors: Barbara Predieri; Patrizia Bruzzi; Elena Bigi; Silvia Ciancia; Simona F Madeo; Laura Lucaccioni; Lorenzo Iughetti Journal: Int J Mol Sci Date: 2020-04-22 Impact factor: 5.923
Authors: Chelsea A O'Driscoll; Leah A Owens; Madeline E Gallo; Erica J Hoffmann; Amin Afrazi; Mei Han; John H Fechner; James J Schauer; Christopher A Bradfield; Joshua D Mezrich Journal: Part Fibre Toxicol Date: 2018-08-24 Impact factor: 9.400