BACKGROUND: Several studies in recent years have linked association between micronutrient levels and various forms of cancer. Copper and zinc have been the most researched micronutrients. AIM: The aim of the study was to evaluate the levels of copper, zinc and iron in saliva of patients with oral leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma. RESULTS: There was a highly significant increase in the level of salivary copper in oral submucous fibrosis patients when compared to controls (P = 0.001). Salivary copper levels were also elevated in oral leukoplakia and oral cancer patients (P = 0.01). There was a significant decrease in the salivary zinc levels in all three study groups when compared to controls (P = 0.001). A highly significant reduction in salivary iron levels was noticed oral submucous fibrosis group. The copper to zinc ratio significantly increased in all the study groups when compared to controls. CONCLUSION: Results suggest that salivary copper zinc and iron could be used as biomarkers for oral precancer and cancer.
BACKGROUND: Several studies in recent years have linked association between micronutrient levels and various forms of cancer. Copper and zinc have been the most researched micronutrients. AIM: The aim of the study was to evaluate the levels of copper, zinc and iron in saliva of patients with oral leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma. RESULTS: There was a highly significant increase in the level of salivary copper in oral submucous fibrosispatients when compared to controls (P = 0.001). Salivary copper levels were also elevated in oral leukoplakia and oral cancerpatients (P = 0.01). There was a significant decrease in the salivary zinc levels in all three study groups when compared to controls (P = 0.001). A highly significant reduction in salivary iron levels was noticed oral submucous fibrosis group. The copper to zinc ratio significantly increased in all the study groups when compared to controls. CONCLUSION: Results suggest that salivary copper zinc and iron could be used as biomarkers for oral precancer and cancer.
Authors: Anderson Barros Archanjo; Arícia Leone Evangelista Monteiro de Assis; Mayara Mota de Oliveira; Suzanny Oliveira Mendes; Aline Ribeiro Borçoi; Lucas de Lima Maia; Rafael Pereira de Souza; Rafael de Cicco; Kelly Cristina Saito; Edna Teruko Kimura; Marcos Brasilino de Carvalho; Fabio Daumas Nunes; Eloiza H Tajara; Marcelo Dos Santos; Breno Valentim Nogueira; Leonardo Oliveira Trivilin; Christiano Jorge Gomes Pinheiro; Adriana Madeira Álvares-da-Silva Journal: Sci Rep Date: 2020-06-25 Impact factor: 4.379
Authors: Juan Aitken Saavedra; Diogo La Rosa Novo; Marcia Foster Mesko; Ana Carolina Uchoa Vasconcellos; Karine Duarte Da Silva; Gabriel Rojas Zuñiga; Ricardo Fernandes Ramires; Sandra Beatriz Chaves Tarquinio Journal: Asian Pac J Cancer Prev Date: 2022-03-01
Authors: Lucille F van Beek; Kristin Surmann; H Bart van den Berg van Saparoea; Diane Houben; Wouter S P Jong; Christian Hentschker; Thomas H A Ederveen; Elena Mitsi; Daniela M Ferreira; Fred van Opzeeland; Christa E van der Gaast-de Jongh; Irma Joosten; Uwe Völker; Frank Schmidt; Joen Luirink; Dimitri A Diavatopoulos; Marien I de Jonge Journal: Virulence Date: 2020-12 Impact factor: 5.882