Anne Troldborg1, Steffen Thiel2, Magdalena Janina Laska2, Bent Deleuran2, Jens Christian Jensenius2, Kristian Stengaard-Pedersen2. 1. From the Department of Rheumatology, Aarhus University Hospital; Department of Clinical Medicine, and Department of Biomedicine, Aarhus University, Aarhus, Denmark.A. Troldborg, MD, PhD candidate, Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University; S. Thiel, Professor; M.J. Laska, PhD, Assistant Professor, Department of Biomedicine, Aarhus University; B. Deleuran, DrMed, Professor, Department of Rheumatology, Aarhus University Hospital and Department of Biomedicine, Aarhus University; J.C. Jensenius, DrMed, DrPhil, Professor, Department of Biomedicine, Aarhus University; K. Stengaard-Pedersen, DrMed, Professor, Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University. annetrol@rm.dk. 2. From the Department of Rheumatology, Aarhus University Hospital; Department of Clinical Medicine, and Department of Biomedicine, Aarhus University, Aarhus, Denmark.A. Troldborg, MD, PhD candidate, Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University; S. Thiel, Professor; M.J. Laska, PhD, Assistant Professor, Department of Biomedicine, Aarhus University; B. Deleuran, DrMed, Professor, Department of Rheumatology, Aarhus University Hospital and Department of Biomedicine, Aarhus University; J.C. Jensenius, DrMed, DrPhil, Professor, Department of Biomedicine, Aarhus University; K. Stengaard-Pedersen, DrMed, Professor, Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University.
Abstract
OBJECTIVE: To examine whether proteins of the lectin pathway of the complement system are involved in systemic lupus erythematosus (SLE) pathogenesis. METHODS: Using time-resolved immunofluorometric assays, plasma levels of mannan-binding lectin (MBL)-associated serine proteases 1 (MASP-1), MASP-2, MASP-3, MBL-associated protein of 19 kDa (MAp19), and MAp44 were determined in 58 patients with SLE and 65 healthy controls (HC). RESULTS: Plasma concentrations in patients with SLE were higher than HC regarding MASP-1, MASP-3, and MAp44 (p < 0.0001, 0.0003, and 0.0013). Complement factor 3 correlated negatively and anti-dsDNA positively with levels of MAp19 (p = 0.0035, p = 0.0133). CONCLUSION: In SLE, plasma levels of MASP and MAp are altered and associated with SLE characteristics, supporting a role in SLE pathogenesis.
OBJECTIVE: To examine whether proteins of the lectin pathway of the complement system are involved in systemic lupus erythematosus (SLE) pathogenesis. METHODS: Using time-resolved immunofluorometric assays, plasma levels of mannan-binding lectin (MBL)-associated serine proteases 1 (MASP-1), MASP-2, MASP-3, MBL-associated protein of 19 kDa (MAp19), and MAp44 were determined in 58 patients with SLE and 65 healthy controls (HC). RESULTS: Plasma concentrations in patients with SLE were higher than HC regarding MASP-1, MASP-3, and MAp44 (p < 0.0001, 0.0003, and 0.0013). Complement factor 3 correlated negatively and anti-dsDNA positively with levels of MAp19 (p = 0.0035, p = 0.0133). CONCLUSION: In SLE, plasma levels of MASP and MAp are altered and associated with SLE characteristics, supporting a role in SLE pathogenesis.
Authors: A Troldborg; S Thiel; C E Mistegaard; A Hansen; T-L Korsholm; K Stengaard-Pedersen; A G Loft Journal: Clin Exp Immunol Date: 2019-10-01 Impact factor: 4.330
Authors: Kristian Juul-Madsen; Anne Troldborg; Thomas R Wittenborn; Mads G Axelsen; Huaying Zhao; Lasse H Klausen; Stefanie Luecke; Søren R Paludan; Kristian Stengaard-Pedersen; Mingdong Dong; Holger J Møller; Steffen Thiel; Henrik Jensen; Peter Schuck; Duncan S Sutherland; Søren E Degn; Thomas Vorup-Jensen Journal: Proc Natl Acad Sci U S A Date: 2021-07-27 Impact factor: 11.205
Authors: Nicholas R Medjeral-Thomas; Anne Troldborg; Nicholas Constantinou; Hannah J Lomax-Browne; Annette G Hansen; Michelle Willicombe; Charles D Pusey; H Terence Cook; Steffen Thiel; Matthew C Pickering Journal: Kidney Int Rep Date: 2017-11-29