Bahman Sotoodian1, Janet Robert2, Muhammad N Mahmood3, Elaine Yacyshyn4. 1. Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, AB, Canada bahman.sotoodian@gmail.com. 2. Department of Medicine, University of Alberta, Edmonton, AB, Canada. 3. Department of Pathology, University of Alberta, Edmonton, AB, Canada. 4. Division of Rheumatology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Abstract
BACKGROUND: IgA vasculitis is a small-vessel vasculitis caused by deposition of IgA antibodies in tissues. IgA nephropathy and IgAV have long been considered related conditions. OBJECTIVE: To assess the prevalence and implications of new-onset Henoch-Schönlein purpura (HSP) after renal transplant in patients with underlying IgA nephropathy. METHODS: The PubMed database was searched for keywords such as IgAV, IgA vasculitis, Henoch-Schönlein purpura, HSP, IgA nephropathy, and renal transplant. RESULTS: Two cases of new-onset IgA vasculitis post-renal transplant after stopping the prednisone or receiving seasonal influenza vaccine have been reported. We report the case of new-onset IgA cutaneous vasculitis in a renal transplant patient with IgA nephropathy after reduction in his prednisone dosage. CONCLUSION: The new development of cutaneous IgA vasculitis is unusual in renal transplant patients with IgA nephropathy. Despite these patients' being immunosuppressed, the presence of IgA vasculitis could signal the recurrence of IgA nephropathy.
BACKGROUND: IgA vasculitis is a small-vessel vasculitis caused by deposition of IgA antibodies in tissues. IgA nephropathy and IgAV have long been considered related conditions. OBJECTIVE: To assess the prevalence and implications of new-onset Henoch-Schönlein purpura (HSP) after renal transplant in patients with underlying IgA nephropathy. METHODS: The PubMed database was searched for keywords such as IgAV, IgA vasculitis, Henoch-Schönlein purpura, HSP, IgA nephropathy, and renal transplant. RESULTS: Two cases of new-onset IgA vasculitis post-renal transplant after stopping the prednisone or receiving seasonal influenza vaccine have been reported. We report the case of new-onset IgA cutaneous vasculitis in a renal transplant patient with IgA nephropathy after reduction in his prednisone dosage. CONCLUSION: The new development of cutaneous IgA vasculitis is unusual in renal transplant patients with IgA nephropathy. Despite these patients' being immunosuppressed, the presence of IgA vasculitis could signal the recurrence of IgA nephropathy.
Authors: Yan Jin; Yanzheng Wang; Sai Wang; Qiongqiong Zhao; Donghua Zhang; Xuan Feng Journal: Evid Based Complement Alternat Med Date: 2021-10-21 Impact factor: 2.629