Yoko Tanaka1, Meryl Brod2, Jeannine R Lane3, Himanshu Upadhyaya1. 1. 1 Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA. 2. 2 The Brod Group, Mill Valley, CA, USA. 3. 3 inVentiv Health, Indianapolis, IN, USA.
Abstract
OBJECTIVE: To estimate a minimal clinically important difference (MCID) on the adult ADHD Quality of Life (AAQoL) scale. METHOD: The MCID was determined from data from short-term ( N = 537) and long-term ( N = 440), placebo-controlled atomoxetine trials in adults with ADHD. For the anchor-based approach, change in clinician-rated Clinical Global Impressions-ADHD-Severity (CGI-ADHD-S) scores was used to derive MCID. For the distribution-based approach, baseline-to-endpoint mean ( SD) changes in AAQoL scores corresponding to 0.5 SD were computed. RESULTS: The MCID was similar (approximately 8-point difference) between the short-term and the long-term treatment groups when either the anchor-based or distribution-based approach was used. CONCLUSION: These results suggest that approximately 8 points in the change from baseline on the AAQoL is a MCID.
RCT Entities:
OBJECTIVE: To estimate a minimal clinically important difference (MCID) on the adult ADHD Quality of Life (AAQoL) scale. METHOD: The MCID was determined from data from short-term ( N = 537) and long-term ( N = 440), placebo-controlled atomoxetine trials in adults with ADHD. For the anchor-based approach, change in clinician-rated Clinical Global Impressions-ADHD-Severity (CGI-ADHD-S) scores was used to derive MCID. For the distribution-based approach, baseline-to-endpoint mean ( SD) changes in AAQoL scores corresponding to 0.5 SD were computed. RESULTS: The MCID was similar (approximately 8-point difference) between the short-term and the long-term treatment groups when either the anchor-based or distribution-based approach was used. CONCLUSION: These results suggest that approximately 8 points in the change from baseline on the AAQoL is a MCID.
Entities:
Keywords:
ADHD; atomoxetine; attention deficit/hyperactivity disorder; quality of life