Literature DB >> 25876218

Doxycycline as a modulator of inflammation in chronic wounds.

James R Wilcox1, D Scott Covington2, Nancy Paez2.   

Abstract

 Doxycycline is a semisynthetic, chemically modified tetracycline compound that is rapidly absorbed and exerts biological effects independent of its antimicrobial activity. One such effect includes the inhibition of matrix metalloproteinases. Doxycycline has a long history as a collagenase inhibitor. This article will describe its mode of action and review its effectiveness in significantly reducing inflammation and elevated levels of proinflammatory cytokines within chronic wounds. .

Entities:  

Year:  2012        PMID： 25876218

Source DB:  PubMed          Journal:  Wounds        ISSN： 1044-7946            Impact factor:   1.546


  8 in total

1.  Novel bioactive tetracycline-containing electrospun polymer fibers as a potential antibacterial dental implant coating.

Authors:  R G Shahi; M T P Albuquerque; E A Münchow; S B Blanchard; R L Gregory; M C Bottino
Journal:  Odontology       Date:  2016-09-01       Impact factor: 2.634

2.  Doxycycline shows dose-dependent changes in hernia repair strength after mesh repair.

Authors:  Job C Tharappel; Jennifer W Harris; Brittany A Zwischenberger; Salomon M Levy; David A Puleo; J Scott Roth
Journal:  Surg Endosc       Date:  2015-08-12       Impact factor: 4.584

3.  Doxycycline alters collagen composition following ventral hernia repair.

Authors:  Job C Tharappel; Jennifer W Harris; Crystal Totten; Brittany A Zwischenberger; John S Roth
Journal:  Surg Endosc       Date:  2016-08-12       Impact factor: 4.584

Review 4.  Selective toxicity of antibacterial agents-still a valid concept or do we miss chances and ignore risks?

Authors:  Axel Dalhoff
Journal:  Infection       Date:  2020-12-23       Impact factor: 7.455

5.  Combined Effect of Shegandilong Granule and Doxycycline on Immune Responses and Protection Against Avian Infectious Bronchitis Virus in Broilers.

Authors:  Haipeng Feng; Xuezhi Wang; Jingyan Zhang; Kang Zhang; Wenshu Zou; Kai Zhang; Lei Wang; Zhiting Guo; Zhengying Qiu; Guibo Wang; Ruihua Xin; Jianxi Li
Journal:  Front Vet Sci       Date:  2021-12-20

6.  Effect of doxycycline and doxycycline with carica papaya on thrombocytopenia and leucopenia in acute dengue fever patients.

Authors:  Vivek Pambhar; Navgeet Mathur; Amit Mehta; Medha Mathur; Dal Chand Kumawat; Ravi Mangalia; Anjana Verma; Ashish Patyal
Journal:  J Family Med Prim Care       Date:  2022-06-30

7.  Doxycycline induces bone repair and changes in Wnt signalling.

Authors:  Kátia do Nascimento Gomes; Ana Paula Negreiros Nunes Alves; Paula Góes Pinheiro Dutra; Glauce Socorro de Barros Viana
Journal:  Int J Oral Sci       Date:  2017-09       Impact factor: 6.344

8.  Autophagy diminishes the early interferon-β response to influenza A virus resulting in differential expression of interferon-stimulated genes.

Authors:  Brieuc P Perot; Jeremy Boussier; Nader Yatim; Jeremy S Rossman; Molly A Ingersoll; Matthew L Albert
Journal:  Cell Death Dis       Date:  2018-05-01       Impact factor: 8.469
  8 in total

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