| Literature DB >> 25875511 |
Xiaoxia Wu1, Liqiang Luo1, Sugeun Yang2, Xuehua Ma, Yonglong Li, Chen Dong, Yuchen Tian, Ling'e Zhang, Zheyu Shen, Aiguo Wu.
Abstract
The detection of circulating tumor cells (CTCs) in the blood of cancer patients is crucial for early cancer diagnosis, cancer prognosis, evaluation of the treatment effect of chemotherapy drugs, and choice of cancer treatment options. In this study, we propose new surface-enhanced Raman scattering (SERS) nanoparticles for the direct detection of CTCs in the blood. Under the optimized experimental conditions, our SERS nanoparticles exhibit satisfying performances for the direct detection of cancer cells in the rabbit blood. A good linear relationship is obtained between the SERS intensity and the concentration of cancer cells in the range of 5-500 cells/mL (R(2) = 0.9935), which demonstrates that the SERS nanoparticles can be used for the quantitative analysis of cancer cells in the blood and the limit of detection is 5 cells/mL, which is lowest compared with the reported values. The SERS nanoparticles also have an excellent specificity for the detection of cancer cells in the rabbit blood. The above results reinforce that our SERS nanoparticles can be used for the direct detection of CTCs in the blood with excellent specificity and high sensitivity.Entities:
Keywords: blood; circulating tumor cells; direct detection; excellent specificity; high sensitivity; surface-enhanced Raman scattering
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Year: 2015 PMID： 25875511 DOI： 10.1021/acsami.5b02276
Source DB: PubMed Journal: ACS Appl Mater Interfaces ISSN： 1944-8244 Impact factor: 9.229